Pendant hydrophile bearing biodegradable compositions and related devices
A composition comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable polyester component and wherein B is the reaction product resulting from the reaction between a diol, having one or more pendant oligomeric or polymeric groups, and A and A′. Additionally, a bioresorbable patch comprising: (a) an adhesion barrier component comprising the composition in the form of a film; and (b) an adhesive component comprising (i) at least one synthetic adhesive polymer and/or (ii) at least one polysaccharide. Also, a method of wound healing, comprising administering the composition or apply the patch to a patient.
1. A bioresorbable patch comprising:
(a) an adhesion barrier component comprising, in the form of a patch, a comprising at least one polymer having the structure A-B-A′, wherein A and A′ may be the same or different and each is a degradable aliphatic polyester component and wherein B is the reaction product resulting from the reaction between A and A′ and a diol, wherein the diol comprises a pendant oligomeric or polymeric oxyalkylene moiety; and
(b) an adhesive component comprising:
(i) at least one synthetic adhesive polymer; and/or
(ii) at least one polysaccharide.
2. The bioresorbable patch of claim 1 , wherein said adhesive polymer is at least one synthetic polymer member selected from the group consisting of polyvinyllactam, polyethyleneglycol, polyethylene glycol-polypropylene glycol copolymers, vinyl acetate homo and copolymers, poly(vinyl alcohol), and blends thereof.
3. The bioresorbable patch of claim 2 , wherein said polysaccharide is at least one member selected from the group consisting of starch, dextran, agar, cellulose, carboxymethyl cellulose (CMC), hydroxypropylcellulose (HPC), chitin, chitosan, alginic acid, hyaluronic acid, chondroitin sulfate, heparin, or their salts, and blends thereof.
4. The bioresorbable patch of claim 3 , wherein A and A′ each comprise a poly(hydroxy carboxylic acid).
5. The bioresorbable patch of claim 4 , wherein the pendant oligomeric or polymeric oxyalkylene moiety comprises a poly(ethylene oxide) unit.
6. The bioresorbable patch of claim 2 , wherein A and A′ each comprise a poly(hydroxy carboxylic acid).
7. The bioresorbable patch of claim 6 , wherein the pendant oligomeric or polymeric oxyalkylene moiety comprises a poly(ethylene oxide) unit.
8. The bioresorbable patch of claim 1 , wherein said polysaccharide is at least one member selected from the group consisting of starch, dextran, agar, cellulose, carboxymethyl cellulose (CMC), hydroxypropylcellulose (HPC), chitin, chitosan, alginic acid, hyaluronic acid, chondroitin sulfate, heparin, or their salts, and blends thereof.
9. The bioresorbable patch of claim 1 , further comprising at least one compatibilizing component.
10. The bioresorbable patch of claim 9 , wherein said compatibilizing component is at least one member selected from the group consisting of hydrogen-bonding materials.
11. The bioresorbable patch of claim 10 , wherein said hydrogen-bonding material is at least one of water, diols, amines, thiols, carboxylic acids, or poly(ethyleneoxide) (PEO) and/or poly(propyleneoxide) (PPO) containing oligomers, polymers and copolymers.
12. The bioresorbable patch of claim 1 comprising an adhesion barrier layer comprising the adhesion barrier component but not the adhesive component, an adhesive layer comprising the adhesive component but not the adhesion barrier component, and a hybrid composite layer at the interface of the adhesion barrier layer and the adhesive layer, wherein the hybrid composite layer comprises the adhesion barrier component and the adhesive component.
13. The bioresorbable patch of claim 12 , wherein the adhesive component comprises polyvinylpyrrolidone.
14. The bioresorbable patch of claim 1 , further comprising at least one bioactive agent.
15. The bioresorbable patch of claim 1 , wherein A and A′ each comprise a poly(hydroxy carboxylic acid).
16. The bioresorbable patch of claim 15 , wherein said poly (hydroxy carboxylic acid) is glycolide, lactide, (β-propiolactone, β-butyrolactone, γ-butyrolactone, δ-valerolactone, ε-caprolactone, 1,5-dioxepan-2-one, pivalolactone, or 1,4-dioxane-2-one.
17. The bioresorbable patch of claim 1 , wherein the pendant oligomeric or polymeric oxyalkylene moiety comprises a poly(ethylene oxide) unit.
18. The bioresorbable patch of claim 16 , wherein the pendant oligomeric or polymeric oxyalkylene moiety comprises a poly(ethylene oxide) unit.
19. A method of wound healing comprising applying the bioresorbable patch of claim 1 to a patient in need thereof.
20. The method of claim 19 , wherein application of said bioresorbable patch is a partial or total replacement for sutures or staples.