Compositions for topical treatment of microbial infections
The present invention provides compositions and methods for topical treatment of infections. The compositions comprise glycerol monolaurate or a derivative thereof, and are administered topically, for example, to treat viral, fungal or bacterial infections.
1. A method of treating or preventing a gram-positive bacterial skin infection, a gram-positive bacterial infection of a wound, or a gram-positive bacterial infection of surgical incision cite in a subject in need thereof, the method comprising the step of topically administering an effective amount of a composition comprising
GML and a non-aqueous gel comprised of a combination of propylene glycol, polyethylene glycol, and cellulose derivative and the non-aqueous gel having a pH from about 4.0 to about 4.5, wherein the non-aqueous gel is at a concentration of about 10% to about 25% of the composition,
to treat or prevent the gram-positive bacterial skin infection, the gram-positive bacterial infection of a wound, or the gram-positive bacterial infection of surgical incision cite in the subject,
wherein GML is present at a concentration of about 10 μg/mL to about 100 mg/mL; and
wherein the GML is the isomer of GML with lauric acid in the 2-position of glycerol.
2. The method of 1 , wherein the non-aqueous composition further comprises a pharmaceutically acceptable topical carrier.
3. The method of 1 , wherein the non-aqueous composition further comprises an accelerant selected from an organic acid, a chelator, an antibiotic agent, an anti-fungal agent, an anti-viral agent, or a combination thereof.
4. The method of 1 , wherein GML comprises about 0.001% (w/v) to about 10% (w/v) of the composition.
5. The method of 1 , further comprising administering a second active agent selected from an antibiotic, an anti-fungal agent, or an anti-viral agent.
6. The method of claim 1 , wherein the gram-positive bacterial infection is a Staphylococcus infection.
7. The method of claim 1 wherein the gram-positive bacterial infection is methicillin-resistant Staphylococcus aureus.
8. The method of 1 , wherein the gram-positive bacterial infection is a Streptococcus infection.
9. The method of 1 , wherein the subject is a human.
10. The method of 1 , the method further comprising using a sponge, wipe, or swab to topically apply the non-aqueous composition.