Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure wherein the material comprises a pair of self assembling complementary polypeptides.
1. A pair of self assembling complementary polypeptides (SACPs) that form tapes, ribbons, fibrils or fibres in a β-sheet tape-like substructure, when a first monomeric peptide is contacted or mixed with its complementary monomeric peptide and wherein the SACPs comprise P 11 -26/27 (SEQ ID NOs: 4 and 5).
2. The SACPs of claim 1 , further comprising a bioactive peptide or a therapeutically active molecule conjugated to the SACPs.
3. A composition, comprising:
tapes, ribbons, fibrils or fibres, wherein each of the tapes, ribbons, fibrils or fibres has an antiparallel arrangement of SACPs in a β-sheet tape-like substructure, wherein the SACPs comprise P 11 -26/27 (SEQ ID NOs: 4 and 5).
4. The composition of claim 3 , wherein the composition comprises SACPs which form ribbons and/or fibrils immediately when a first monomeric peptide contacts a second complementary monomeric peptide.
5. The composition of claim 3 , wherein the SACPs further comprise a bioactive peptide or a therapeutically active molecule conjugated to the SACPs.
6. The composition of claim 3 , wherein the composition comprises fibrils, and wherein the fibrils are comprised in a network of fibrils interconnected at fibre-like junctions.
7. The composition of claim 3 , wherein the composition comprises a dental product.
8. The composition of claim 7 , wherein the dental product is a dental repair, dental treatment, or dental reconstruction product.
9. The composition of claim 3 , wherein the composition is in the form of a tissue engineering scaffold.
10. The composition according to claim 9 , wherein the scaffold is seeded with cells.
11. The composition of claim 3 , wherein the material comprises a tissue repair product.
12. The composition of claim 3 , wherein the material comprises a wound healing product.
13. The composition of claim 3 , wherein the material comprises a skin treatment.
14. The composition of claim 3 , wherein the composition comprises a hair care product.
15. The composition of claim 3 , wherein the composition is part of a bioresponsive and biocompatible surface.
16. The composition of claim 3 , wherein the composition is a template for nucleation and growth of inorganic materials.
17. The composition of claim 3 , wherein the composition comprises a continuous filament yarn, staple, floc, cord, or fabric.
18. The composition of claim 3 , wherein the composition comprises a bone reconstruction product.