Tissue sampling devices, systems and methods
Methods, devices, and systems are described herein that allow for improved sampling of tissue from remote sites in the body. A tissue sampling device comprises a handle allowing single hand operation. In one variation the tissue sampling device includes a blood vessel scanning means and tissue coring means to excise a histology sample from a target site free of blood vessels. The sampling device also includes an adjustable stop to control the depth of needle penetration. The sampling device may be used through a working channel of a bronchoscope.
1. A tissue sampling system for obtaining a core of tissue from a sample area, the system comprising:
a tissue sampling device, the device comprising:
an elongate sheath having a flexibility to advance through tortuous airway anatomy;
a shaft removably disposed with the sheath, where the shaft and sheath are moveable relative to one another, the shaft comprising a proximal section and a distal section, and a lumen extending there through;
a coring tip located at the distal section of the shaft, the coring tip having a tissue cutting distal end, and a cavity therein adapted to cut and capture a tissue sample shaped as a long core upon advancement of the coring tip through a target tissue, the cavity being in fluid communication with the lumen; and
a handle comprising a single-handed actuation assembly operative to advance the coring tip a pre-determined distance from the sheath at a velocity and force which penetrates the target tissue surface and captures the tissue sample in the shape of the long core; and
at least one device advanceable from the sheath.
2. The system of claim 1 , wherein the at least one device is an ultrasound probe.
3. The system of claim 1 , wherein the at least one device is a fiducial.
4. The system of claim 1 , wherein the at least one device is a brachytherapy seed.
5. The system of claim 1 , further comprising a flexibility means to adjust the flexibility of the tissue sampling device.
6. The system of claim 5 , wherein the flexibility means comprises a stylet, said stylet comprising a stylet tip, and said stylet adapted to be locked in a position within said lumen of the shaft such that the stylet tip is in the vicinity of said coring tip and proximal to the coring tip.