IP Library › Granted Patent US 9,642,544
Granted Patent B2
US 9,642,544 · App. 15/071,915 · Granted May 9, 2017

Systems, apparatuses and methods for sensing fetal activity

Inventors: Oren Oz (Modiin, IL); Amit Kam (Tel Aviv, IL); Nathan Intrator (Tel Aviv, IL)
A61B5/02411A61B5/0245A61B5/0255A61B5/02405A61B5/04014A61B5/04017A61B5/0444A61B5/0456A61B5/04525A61B5/4362A61B5/6823A61B5/7203A61B5/725A61B5/726A61B5/7221A61B7/04
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Quick Facts
Patent No.
US 9,642,544
App. No.
15/071,915
Granted
May 9, 2017
Kind
B2
Abstract

The invention provides systems and methods for monitoring the wellbeing of a fetus by the non-invasive detection and analysis of fetal cardiac activity data, utilizing a plurality of acoustic sensors.

Claims (71)

1. A computer-implemented method, comprising:

receiving, by at least one computer processor executing specific programmable instructions configured for the method, a plurality of Phonocardiogram (PCG) signals data inputs from a plurality of acoustic sensors;

digital signal filtering, by the at least one computer processor, utilizing a plurality of bandpass filters, the plurality of PCG signals data inputs to form a plurality of filtered PCG outputs, wherein the plurality of bandpass filters comprises a L number of bandpass filters, wherein each bandpass filter outputs a K number of filtered PCG outputs;

wavelet denoising, by the at least one computer processor, a first subset of filtered PCG outputs of the plurality of filtered PCG outputs to form a M number of denoised filtered PCG outputs, wherein M is equal to L multiply by K, wherein the wavelet denoising comprises:

deconstructing, by the at least one computer processor, each filtered PCG output to generate a plurality of transform coefficients, by irrelatively passing each filtered PCG output through a succession of low and high pass filters,

identifying, by the at least one computer processor, a subset of heartbeat-carrying transform coefficients from the plurality of transform coefficients, and

reconstructing, by the at least one computer processor, the subset of heartbeat-carrying transform coefficients to form the M number of denoised filtered PCG outputs;

transforming, by the at least one computer processor, utilizing an Independent-Component-Analysis (ICA), a second subset of filtered PCG outputs of the plurality of filtered PCG outputs to form the M number of filtered ICA transforms;

transforming, by the at least one computer processor, utilizing the Independent-Component-Analysis (ICA), a first portion of the second subset of denoised filtered PCG outputs to form the M number of denoised filtered ICA transforms;

compiling, by the at least one computer processor, a S number of a plurality of detection heartbeat (DH) inputs, comprising:

i) the M number of filtered PCG outputs,

ii) the M number of the denoised filtered PCG outputs,

iii) the M number of the filtered ICA transforms, and

iv) the M number of the denoised filtered ICA transforms;

detecting, by the at least one computer processor, beat locations of beats in each of DH inputs;

calculating, by the at least one computer processor, a confidence score that describes a probability that the beats in each DH input of the plurality of DH inputs represent actual heartbeats and not a noise;

dividing, by the at least one computer processor, the plurality of DH inputs into at least two groups:

i) a first group of DH inputs containing fetal heartbeats,

ii) a second group of DH inputs containing maternal heartbeats;

selecting, by the at least one computer processor, from the first group of DH inputs, at least one particular fetal DH input that contains the fetal heartbeat based on a first confidence score of the at least one particular fetal DH input; and

selecting, by the at least one computer processor, from the second group of DH inputs, at least one particular maternal DH input that contains the maternal heartbeat, based on a second confidence score of the at least one particular maternal DH input.

2. The computer-implemented method of claim 1 , wherein K is equal to a number of the plurality of acoustic sensors, and L is equal to 6.

3. The computer-implemented method of claim 1 , wherein each filter of the plurality of bandpass filters has a bandwidth of 10-100 Hz and a frequency range of 5-110 HZ.

4. The computer-implemented method of claim 1 , wherein the detecting of the beat locations of the beats in each of DH inputs, comprising:

calculating, by the at least one computer processor, a predetermined transform filter;

iteratively repeating, by the at least one computer processor, based on a predetermined average window length of the predetermined transform filter:

identifying, in each DH input, a subset of peaks having a predetermined shape and a predetermined size, and

selecting a group of peaks from the subset of peaks, wherein the group of peaks has the smallest variance measure;

calculating, by the at least one computer processor, initial locations of the beats.

5. The computer-implemented method of claim 1 , wherein the calculating the confidence score, comprising:

generating, by the at least one computer processor, a beat-by-beat heartbeat graph for each DH input based on the beat locations.

6. The computer-implemented method of claim 1 , wherein the dividing the plurality of DH inputs into the first group of DH inputs containing fetal heartbeats and the second group of DH inputs containing maternal heartbeats, comprising:

clustering, by the at least one computer processor, the beats of each DH input according to each beat value; and

assigning, by the at least one computer processor, a particular DH input having a higher average beat rate into the first group of DH inputs containing fetal heartbeats.

7. A specifically programmed computer system, comprising:

at least one specialized computer machine, comprising:

a non-transient memory, electronically storing particular computer executable program code; and

at least one computer processor which, when executing the particular program code, becomes a specifically programmed computing processor that is configured to at least perform the following operations:

receiving a plurality of Phonocardiogram (PCG) signals data inputs from a plurality of acoustic sensors;

digital signal filtering, utilizing a plurality of bandpass filters, the plurality of PCG signals data inputs to form a plurality of filtered PCG outputs, wherein the plurality of bandpass filters comprises a L number of bandpass filters, wherein each bandpass filter outputs a K number of filtered PCG outputs;

wavelet denoising a first subset of filtered PCG outputs of the plurality of filtered PCG outputs to form a M number of denoised filtered PCG outputs, wherein M is equal to L multiply by K, wherein the wavelet denoising comprises:

deconstructing each filtered PCG output to generate a plurality of transform coefficients, by irrelatively passing each filtered PCG output through a succession of low and high pass filters,

identifying a subset of heartbeat-carrying transform coefficients from the plurality of transform coefficients, and

reconstructing the subset of heartbeat-carrying transform coefficients to form the M number of denoised filtered PCG outputs;

transforming, utilizing an Independent-Component-Analysis (ICA), a second subset of filtered PCG outputs of the plurality of filtered PCG outputs to form the M number of filtered ICA transforms;

transforming, utilizing the Independent-Component-Analysis (ICA), a first portion of the second subset of denoised filtered PCG outputs to form the M number of denoised filtered ICA transforms;

compiling a S number of a plurality of detection heartbeat (DH) inputs, comprising:

i) the M number of filtered PCG outputs,

ii) the M number of denoised filtered PCG outputs,

iii) the M number of filtered ICA transforms, and

iv) the M number of denoised filtered ICA transforms;

detecting beat locations of beats in each of DH inputs;

calculating a confidence score that describes a probability that the beats in each DH input of the plurality of DH inputs represent actual heartbeats and not a noise;

dividing the plurality of DH inputs into at least two groups:

i) a first group of DH inputs containing fetal heartbeats,

ii) a second group of DH inputs containing maternal heartbeats;

selecting, from the first group of DH inputs, at least one particular fetal DH input that contains the fetal heartbeat based on a first confidence score of the at least one particular fetal DH input; and

selecting, from the second group of DH inputs, at least one particular maternal DH input that contains the maternal heartbeat, based on a second confidence score of the at least one particular maternal DH input.

8. The specifically programmed computer system of claim 7 , wherein K is equal to a number of the plurality of acoustic sensors, and L is equal to 6.

9. The specifically programmed computer system of claim 7 , wherein each filter of the plurality of bandpass filters has a bandwidth of 10-100 Hz and a frequency range of 5-110 HZ.

10. The specifically programmed computer system of claim 7 , wherein the detecting of the beat locations of the beats in each of DH inputs, comprising:

calculating a predetermined transform filter;

iteratively repeating, based on a predetermined average window length of the predetermined transform filter:

identifying, in each DH input, a subset of peaks having a predetermined shape and a predetermined size, and

selecting a group of peaks from the subset of peaks, wherein the group of peaks has the smallest variance measure;

calculating initial locations of the beats.

11. The specifically programmed computer system of claim 7 , wherein the calculating the confidence score, comprising:

generating a beat-by-beat heartbeat graph for each DH input based on the beat locations.

12. The specifically programmed computer system of claim 7 , wherein the dividing the plurality of DH inputs into the first group of DH inputs containing fetal heartbeats and the second group of DH inputs containing maternal heartbeats, comprising:

clustering the beats of each DH input according to each beat value; and

assigning a particular DH input having a higher average beat rate into the first group of DH inputs containing fetal heartbeats.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 7, 2025
From: NUVO GROUP LTD.
To: NUVO INT'L GROUP INC.
Reel/Frame 071819/0890 →
SECURITY INTEREST Recorded Jan 24, 2024
From: NUVO GROUP LTD.
To: GAINGELS 10X CAPITAL DIVERSITY FUND I, LP
Reel/Frame 066366/0843 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 9, 2016
From: KAM, AMIT; OZ, OREN; INTRATOR, NATHAN; MHAJNA, MUHAMMED
To: NUVO GROUP LTD.
Reel/Frame 038861/0996 →
Continuity (3)
Continuation In Part 14921489 · Oct 23, 2015
Provisional Application 62133485 · Mar 16, 2015
Related Publication 20160270674A1 · Sep 22, 2016