IP Library › Granted Patent US 11,464,859
Granted Patent B2
US 11,464,859 · App. 15/077,373 · Granted Oct 11, 2022

Pharmaceutical compositions comprising sodium meta arsenite for treatment of multiple myeloma

Inventor: Bernardus Rademaker (Onstwedde, NL)
Assignee: KOMINOX, INC.
A61K45/06A61K33/36A61P7/00A61P35/00A61P35/02A61P35/04
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Quick Facts
Patent No.
US 11,464,859
App. No.
15/077,373
Granted
Oct 11, 2022
Kind
B2
Abstract

The present application relates to pharmaceutical compositions and methods for treatment of urogenital diseases and bone metastasis in a human, which pharmaceutical composition contains an effective amount of arsenous acid alkaline or earth alkaline metal salt and/or a pharmaceutically acceptable adjuvant. According to the present invention, the alkaline arsenous acid metal salt is sodium meta-arsenita (AsO 2 Na) or potassium meta-arsenite (AsO 2 K). The effective amount of arsenous acid alkaline or earth alkaline metal salt is 0.0001-1500 mg/kg, preferably 1-1000 mg/kg, more preferably 1-150 mg/kg, and most preferably 50-100 mg/kg of body weight/day. The administration form of the pharmaceutical compositions of the invention is preferably oral, such as a tablet, capsule, powder and/or solution with a pharmaceutically acceptable carrier, diluent or excipient.

Claims (4)

1. A method of treating multiple myeloma in a patient comprising administering a composition comprising a therapeutically effective amount of sodium meta arsenite to the patient, wherein the sodium meta arsenite composition is administered orally.

2. The method of claim 1 , wherein the therapeutically effective amount is from 2.5 to 15 mg.

3. The method of claim 1 further comprising administering radiation therapy to the patient.

4. The method of claim 1 further comprising administering a chemotherapy agent to the patient.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2021
From: KOMIPHARM INTERNATIONAL CO., LTD.
To: KOMINOX, INC.
Reel/Frame 056293/0449 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 19, 2021
From: RADEMAKER, BERNARDUS
To: KOMIPHARM INTERNATIONAL CO., LTD.
Reel/Frame 056293/0474 →
CORRECTIVE ASSIGNMENT TO CORRECT THE THE INVENTORS NAME PREVIOUSLY RECORDED AT REEL: 021513 FRAME: 0396. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded May 19, 2021
From: RADEMAKER, BERNARDUS
To: KOMIPHARM INTERNATIONAL CO., LTD.
Reel/Frame 056296/0273 →
Priority Claims (1)
EP 05076071 · May 9, 2005 · regional
Continuity (2)
Division 11631962
Related Publication 20160199411A1 · Jul 14, 2016