OMEGA-3 PHOSPHOLIPID SUPPLEMENTS FOR IMPROVED BRAIN MATURITY
The invention relates to omega-3 phospholipid supplements for use in adolescents, and in particular to use omega-3 phospholipid supplements to improve or support brain maturity age. In preferred embodiments, the omega-3 phospholipid is krill oil.
1 . A method of improving or supporting brain maturity age in a subject in need thereof comprising:
administering an omega-3 phospholipid supplement to said subject under conditions such that the brain maturity age of the subject is improved.
2 . The method of claim 1 , wherein said omega-3 phospholipid supplement is a krill oil, fish oil, fish roe oil, or fish byproduct oil.
3 . The method of claim 2 , wherein said krill oil comprises from about 35% to 60% phospholipids on a w/w basis; from about 20% to 45% triglycerides on a w/w basis; and from about 50 to about 2500 mg/kg astaxanthin.
4 . The method of claim 3 , wherein said krill oil comprises from about 3% to 10% ether phospholipids on a w/w basis, so that the total amount of ether phospholipids and non-ether phospholipids in the composition is from about 48% to 60% on a w/w basis.
5 . The method of claim 4 , wherein said krill oil comprises from about 25% to 30% omega-3 fatty acids as a percentage of total fatty acids and wherein from about 80% to 90% of said omega-3 fatty acids are attached to said phospholipids.
6 . The method of claim 5 , wherein said krill oil comprises from about 100 to about 2500 mg/kg astaxanthin.
7 . The method of claim 1 , wherein said omega-3 supplement comprises from about 1% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in the composition is from about 30% to 60% w/w; from about 20% to 50% w/w triglycerides; from about 100 to about 2500 mg/kg astaxanthin; and from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said composition, wherein from about 70% to 95% of said omega-3 fatty acids are attached to said phospholipids.
8 . The method of claim 1 , wherein said omega-3 is selected from EPA and DHA and combinations thereof.
9 . The method of claim 1 , wherein said subject is an adolescent.
10 . The method of claim 9 , wherein said adolescent is a male.
11 . The method of claim 1 , wherein said administration is oral.
12 . The method of claim 1 , wherein said omega-3 phospholipid supplemented is administered a daily dosage of from about 3 grams to about 6 grams per day.
13 . The method of claim 12 , wherein said daily dose is administered in two doses of from 1.5 to 3 grams in the morning and evening.
14 . The method of claim 1 , wherein said subject has been diagnosed with ADHD.
15 . The method of claim 1 , wherein said brain maturation age is calculated by comparison of EEG measurements with reference EEG measurements.
16 . A method of improving or supporting brain maturity age in a subject in need thereof comprising:
administering a krill oil supplement to said subject under conditions such that the brain maturity age of the subject is improved, wherein said krill oil supplement comprises from about 35% to 60% phospholipids on a w/w basis, from about 20% to 45% triglycerides on a w/w basis, and from about 50 to about 2500 mg/kg astaxanthin, and wherein said brain maturation age is calculated by comparison of EEG measurements with reference EEG measurements.
17 . The method of claim 16 , wherein said subject is an adolescent male.
18 . The method of claim 16 , wherein said administration is oral.
19 . The method of claim 16 , wherein said omega-3 phospholipid supplemented is administered a daily dosage of from about 3 grams to about 6 grams per day.
20 . The method of claim 19 , wherein said daily dose is administered in two doses of from 1.5 to 3 grams in the morning and evening.