IP Library › Granted Patent US 10,576,166
Granted Patent B2
US 10,576,166 · App. 15/092,226 · Granted Mar 3, 2020

Liver specific delivery of messenger RNA

Inventors: Frank DeRosa (Chelmsford, MA); Michael Heartlein (Boxborough, MA)
Assignee: Translate Bio, Inc.
A61K48/0033A61K9/0019A61K9/1271A61K9/1272A61K31/7105A61K48/005A61K48/0008C07J43/003C12N15/67
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Quick Facts
Patent No.
US 10,576,166
App. No.
15/092,226
Granted
Mar 3, 2020
Kind
B2
Abstract

Disclosed herein are compositions and methods of modulating the expression of gene or the production of a protein by transfecting target cells with nucleic acids. The compositions disclosed herein demonstrate a high transfection efficacy and are capable of ameliorating diseases associated with protein or enzyme deficiencies.

Claims (1)

1. The cationic lipid:

Assignments (3)
CHANGE OF NAME Recorded Jul 20, 2017
From: RANA THERAPEUTICS, INC.
To: TRANSLATE BIO, INC.
Reel/Frame 043267/0165 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 6, 2017
From: SHIRE HUMAN GENETIC THERAPIES, INC.
To: RANA THERAPEUTICS, INC.
Reel/Frame 042177/0032 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 15, 2016
From: DEROSA, FRANK; HEARTLEIN, MICHAEL
To: SHIRE HUMAN GENETIC THERAPIES, INC.
Reel/Frame 040992/0902 →
Cited By (2)
US 12,458,604 US 12,576,040