Granted Patent B2

US 12,576,040 · App. 17/500,486 · Granted Mar 17, 2026

Inventors: Michael Daro Buschmann (Fairfax, VA); Mikell Paige (Fairfax, VA); Suman Alishetty (Fairfax, VA); Manuel Carrasco (Fairfax, VA); Mohamad Gabriel Alameh (Fairfax, VA); Drew Weissman (Fairfax, VA)

Assignees: The Trustees of the University of Pennsylvania; George Mason Research Foundation, Inc.

A61K9/5123A61K9/127A61K31/7088A61K31/7105A61K47/18A61K47/28A61P37/04B82Y5/00C07C229/16C07D207/09C07D211/26C07D295/13C12N15/88A61K48/00

Abstract

Claims (26)

1 . A compound of Formula III:

wherein each of R 1 , R 2 , R 11 , and R 12 is independently selected from the group consisting of H, optionally substituted C 1 -C 12 alkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 4 -C 6 heterocycloalkyl, optionally substituted C 4 -C 6 alkylcycloalkyl, optionally substituted C 4 -C 6 aryl, optionally substituted C 3 -C 6 heteroaryl, optionally substituted C 4 -C 8 aryloxy, optionally substituted C 7 -C 10 arylalkyl; optionally substituted C 5 -C 10 heteroarylalkyl group, and optionally substituted amine;

wherein R 1′ is selected from the group consisting of H, C 1 -C 12 alkyl, optionally substituted C 2 -C 12 alkenyl, optionally substituted C 2 -C 12 alkynyl, optionally substituted C 3 -C 6 cycloalkyl, optionally substituted C 4 -C 6 heterocycloalkyl, optionally substituted C 4 -C 6 alkylcycloalkyl, optionally substituted C 4 -C 6 aryl, optionally substituted C 3 -C 6 heteroaryl, optionally substituted C 4 -C 8 aryloxy, optionally substituted C 7 -C 10 arylalkyl; optionally substituted C 5 -C 10 heteroarylalkyl group, and optionally substituted amine;

wherein each of R 3 and R 4 is independently selected from the group consisting of optionally substituted branched C 1 -C 22 alkyl and optionally substituted C 2 -C 22 alkenyl;

wherein each of R 5 , R 6 , R 7 , R 8 , R 9 , and R 10 is independently selected from the group consisting of H, OH, halo, phenyl, benzyl, optionally substituted C 1 -C 22 alkyl, optionally substituted C 2 -C 22 alkenyl, and optionally substituted C 2 -C 22 alkynyl;

wherein each of x, y, and z is independently an integer selected from 0-10;

wherein G and Q are each N;

wherein each of m and n is 2; and

wherein each of L 1 and L 2 is independently selected from the group consisting of OC(═O)— and C(═O)O—.

2 . The compound of claim 1 , wherein the compound has the following structure:

3 . The compound of claim 1 , wherein the compound has the following structure:

4 . The compound of claim 1 , wherein the compound has the following structure:

5 . The compound of claim 1 , wherein the compound has the following structure:

6 . The compound of claim 1 , wherein the compound has the following structure:

7 . The compound of claim 1 , wherein the compound has the following structure:

8 . The compound of claim 1 wherein x is 2, 3, or 4.

9 . The compound of claim 1 , wherein y is 2, 3, or 4.

10 . The compound of claim 1 , wherein z is 2, 3, or 4.

11 . The compound of claim 1 , wherein R 3 and R 4 are each optionally substituted branched C 1 -C 22 alkyl.

12 . The compound of claim 2 , wherein

R 3 and R 4 are each optionally substituted branched C 1 -C 22 alkyl;

R 1′ is C 1 -C 12 alkyl;

x is 2, 3, or 4;

y is 2, 3, or 4; and

z is 2, 3, or 4.

13 . The compound of claim 1 , wherein R 1′ is C 1 -C 12 alkyl.

Assignments (6)

Continuity (5)

References Cited (400)