Method of treating onychomycosis
This application is directed to a method of treating onychomycosis by applying a phototherapeutic agent to a nail structure, waiting for a period of at least three days, and exposing the nail to light that causes an activation reaction. The phototherapeutic agent may be amino levulinic acid, alkylated derivatives of ALA, and their pharmaceutically acceptable salts.
1. A method of treating onychomycosis comprising the steps of:
applying aminolevulinic acid (ALA) or its pharmaceutically acceptable salt to a nail structure of a subject, wherein the subject has onychomycosis of the nail structure;
allowing a waiting period of between 5 days and 30 days after applying ALA; and
exposing the nail to a light after the waiting period, wherein the light causes an activation reaction.
2. The method of claim 1 , wherein the waiting period is at least 10 days.
3. The method of claim 1 , wherein the waiting period is at least 20 days.
4. The method of claim 1 , wherein the waiting period is between 10 and 20 days.
5. The method of claim 1 , wherein the waiting period is between 10 and 30 days.
6. The method of claim 1 , wherein the waiting period is between 20 and 30 days.
7. The method of claim 1 , wherein the light emits red light in the 600-650 nm wavelength range.
8. A method of treating onychomycosis comprising the following steps:
applying a solution to a nail structure of a subject, wherein the solution comprises
aminolevulinic acid (ALA) or its pharmaceutically acceptable salt at a concentration of 5%-20% of the volume of the solution, and wherein the subject has onychomycosis of the nail structure;
allowing a waiting period of between 10 days and 30 days after applying ALA; and
exposing the nail to a light after the waiting period, wherein the light emits red light in the 600-650 nm wavelength range.
9. A method of treating onychomycosis comprising the following steps:
applying a solution to a nail structure of a subject, wherein the solution comprises
aminolevulinic acid (ALA) or its pharmaceutically acceptable salt at a concentration of 5%-20% of the volume of the solution, and wherein the subject has onychomycosis of the nail structure;
allowing a waiting period of between 5 days and 30 days after applying ALA; and
exposing the nail to a light after the waiting period, wherein the light causes an activation reaction.
10. The method of claim 9 , wherein the light emits red light in the 600-650 nm wavelength range.
11. The method of claim 9 , wherein the waiting period is at least 10 days.