MACROCYCLIC INHIBITORS OF FLAVIVIRIDAE VIRUSES
Provided are compounds of Formula I: and pharmaceutically acceptable salts and esters thereof. The compounds, compositions, and methods provided are useful for the treatment of virus infections, particularly hepatitis C infections.
1 - 37 . (canceled)
38 . A method of treating a Flaviviridae viral infection in a human patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound selected from the group consisting of:
or a pharmaceutically acceptable salt, isotope, stereoisomer, mixture of stereoisomers, tautomer, ester or prodrug thereof.
39 . A method according to claim 38 wherein the compound is
or a pharmaceutically acceptable salt, isotope, stereoisomer, mixture of stereoisomers, tautomer, ester or prodrug thereof.
40 . A method according to claim 38 wherein the compound is
41 . A method according to claim 38 wherein the Flaviviridae infection is caused by a virus selected from the group consisting of West Nile virus (WNV) Japanese encephalitis virus (JEV), tick-borne encephalitis virus, Junjin virus, Murray Valley encephalitis, St Louis enchaplitis, Omsk hemorrhagic fever virus and Zika virus.
42 . A method according to claim 38 wherein the Flaviviridae infection is caused by Zika virus.