Base metal catalyzed borylation of arenes and aromatic heterocycles
In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as catalysts for borylation of arenes and aromatic heterocycles.
1. A cobalt complex is of Formula (IV):
wherein R 1 -R 4 are independently selected from the group consisting of hydrogen and alkyl, and wherein R 5 -R 7 are independently selected from the group consisting of hydrogen, alkyl, and heteroalkyl; and
wherein E 1 and E 2 are independently selected from the group consisting of CR 8 , and C(R 8 ) 2 , wherein R 8 is selected from the group consisting of hydrogen, and alkyl; and
wherein G 1 and G 2 are independently selected from N and P; and
and
and wherein X is R 13 COO—, where R 13 is alkyl.
2. The cobalt complex of Formula (IV), wherein G 1 and G 2 are not each P.
3. The cobalt complex of claim 1 , wherein R 1 -R 4 are independently alkyl.
4. The cobalt complex of claim 3 having the structure:
5. The cobalt complex of claim 3 , having the structure:
6. A cobalt complex is of Formula (IV):
wherein R 1 -R 4 are independently selected from the group consisting of hydrogen and alkyl, and wherein R 5 -R 7 are independently selected from the group consisting of hydrogen, alkyl, and heteroalkyl; and
wherein E 1 and E 2 are independently selected from the group consisting of CR 8 , and C(R 8 ) 2 , wherein R 8 is selected from the group consisting of hydrogen, and alkyl; and
wherein G 1 and G 2 are independently selected from N and P; and
and
and wherein X is R 13 COO—, where R 13 is alkyl and
wherein the cobalt complex of Formula (IV) is operable to participate in borylation of an arene or aromatic heterocycle.
7. The cobalt complex of claim 6 , wherein R 1 -R 4 are independently alkyl.
8. The cobalt complex of claim 7 having the structure:
9. The cobalt complex of claim 7 , having the structure: