IP Library › Granted Patent US 9,783,511

Granted Patent B2

US 9,783,511 · App. 15/103,409 · Granted Oct 10, 2017

Carbamate benzoxazine propionic acids and acid derivatives for modulation of RORgamma activity and the treatment of disease

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Patent No.: US 9,783,511
App. No.: 15/103,409
Granted: Oct 10, 2017
Kind: B2

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Abstract

The invention provides certain benzoxazine compounds of the Formula (I) or pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R a1 , R a2 , R b1 , R b2 , R c , R d , and Cy are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds of the Formula (I) or pharmaceutically acceptable salts thereof, and methods of using the compounds of the Formula (I) or pharmaceutically acceptable salts thereof or pharmaceutical compositions comprising the same for treating diseases or conditions mediated by RORgammaT.

Claims (353)

1. A compound of the Formula (I)

or a pharmaceutically acceptable salt thereof,

wherein:

R 1 is H or C 1 -C 3 alkyl,

R 2 is H, C 1 -C 3 alkyl, or halo;

R a1 and R a2 are independently H, C 1 -C 3 alkyl, trifluoromethyl, or cyclopropyl;

R b1 and R b2 are independently H, C 1 -C 3 alkyl, trifluoromethyl, hydroxyl, hydroxymethyl, or cyclopropyl;

alternatively:

(a.) R a1 and R b1 together with the carbon atoms to which they are attached form a C 3 -C 6 cycloalkyl ring;

(b.) R a1 and R b1 together form a second bond; or

(c.) R b1 and R b2 together with the carbon atom to which they are attached form a C 3 -C 6 cycloalkyl ring;

R c is

(a.) H or

(b.) C 1 -C 6 alkyl;

R d is

(a.) C 1 -C 8 alkyl, wherein said C 1 -C 8 alkyl of R d is unsubstituted or independently substituted by 1 to 6 halo, C 1 -C 3 alkoxy, hydroxy, cyano, trimethylsilyl, or methylsulfonyl;

(b.) C 2 -C 8 alkenyl, wherein said C 2 -C 8 alkenyl of R d is unsubstituted or independently substituted by 1 to 6 fluoro or cyano; or

(c.) a group of the formula -M-R CH ; wherein

M is

(i.) a bond; or

(ii.) C 1 -C 6 alkylene, wherein said C 1 -C 6 alkylene of M is unsubstituted or substituted by 1 to 6 fluoro;

R CH is a ring selected from the group consisting of

(i.) C 3 -C 9 mono- or bicycloalkyl;

(ii.) phenyl; and

(iii.) a 3- to 6-membered heterocyclyl, wherein said heterocyclyl of R CH contains 1 to 2 heteroatoms independently selected from the group consisting of N, O, and S;

wherein R CH is unsubstituted or independently substituted by 1 to 4 halo, C 1 -C 3 alkyl, C 1 -C 3 trifluoroalkyl, cyano, C 1 -C 4 alkylcarbonylamino, or oxo;

Cy is

(a.) phenyl;

(b.) a 5- to 7-membered, monocyclic heterocyclyl containing 1 to 3 heteroatoms independently selected from the group consisting of N, O, and S; or

(c.) C 3 -C 6 cycloalkyl;

wherein Cy is unsubstituted or independently substituted by 1 to 4 R k moieties selected from the group consisting of:

(i.) C 1 -C 6 alkyl, wherein said C 1 -C 6 alkyl is unsubstituted or independently substituted by 1 to 3 hydroxy or fluoro;

(ii.) C 1 -C 6 alkoxy, wherein said C 1 -C 6 alkoxy is unsubstituted or independently substituted by 1 to 3 fluoro, hydroxy, methoxy, or phenyl;

(iii.) —N(R e ) 2 ;

(iv.) —O(CH 2 ) n1 C(O)N(R e ) 2 ;

(v.) —O(CH 2 ) n2 CO 2 R f ;

(vi.) hydroxyl;

(vii.) oxo;

(viii.) halo;

(ix.) C 1 -C 3 alkylsulfonyl;

(x.) cyano;

(xi.) oxetanyl;

(xii.) cyclopropyl; and

(xiii.) —SF 5 ;

or alternatively, two R k moieties, when substituted on adjacent ring atoms of Cy, form a second ring, wherein said second ring is a 5- to 7-membered saturated, partially saturated, or aromatic ring system that contains 0, 1, or 2 heteroatoms independently selected from the group consisting of N, O, and S; wherein said second ring is unsubstituted or substituted by 1 to 3 R k moieties independently selected from (i)-(xii);

each R e is independently H or C 1 -C 3 alkyl,

R f is H or C 1 -C 3 alkyl;

the subscript n1 is 1, 2, or 3; and

the subscript n2 is 1, 2, or 3.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R a1 and R a2 are H.

3. The compound of claim 2 or a pharmaceutically acceptable salt thereof, wherein R b1 is H.

4. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is H.

5. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R d is C 1 -C 8 alkyl, wherein said C 1 -C 8 alkyl of R d is unsubstituted or independently substituted by 1 to 6 halo, C 1 -C 3 alkoxy, hydroxy, cyano, trimethylsilyl, or methylsulfonyl.

6. The compound of claim 5 or a pharmaceutically acceptable salt thereof, wherein R d is

7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein Cy is a group of the formula

wherein the subscript s is 0, 1, 2, or 3.

8. The compound of claim 1 , having the Formula (TB)

wherein

Cy is

R 2 is H or F;

the subscript s is 0, 1, 2, or 3;

R b1 and R b2 are independently H or CH 3 ; and

R d1 is CH 3 , CHF 2 , CH 2 F, or CF 3 ;

or a pharmaceutically acceptable salt thereof.

9. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein each R k is independently:

(i.) C 1 -C 6 alkyl, wherein said C 1 -C 6 alkyl is unsubstituted or independently substituted by 1 to 3 hydroxy or fluoro;

(ii.) C 1 -C 6 alkoxy, wherein said C 1 -C 6 alkoxy is unsubstituted or independently substituted by 1 to 3 fluoro, hydroxy, methoxy, or phenyl;

(iii.) a halo selected from fluoro or chloro;

(iv.) cyano; or

alternatively, two R k moieties, when substituted on adjacent ring atoms of Cy, form a second ring, wherein said second ring is a 5- to 6-membered partially saturated or aromatic ring system that contains 0 or 1 N atom; wherein said second ring is unsubstituted or substituted by 1 to 2 R k moieties independently selected from (i)-(iv).

10. The compound of claim 8 or a pharmaceutically acceptable salt thereof,

wherein Cy is:

wherein

the subscript p is 1 or 2; and

s is 0, 1, or 2.

11. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein Cy is

wherein R k3 and R k4 are independently F, Cl, CF 3 , methyl, methoxy, cyclopropyl, or cyano.

12. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein Cy is

wherein

R k1 is C 1 -C 6 alkyl or CH 2 CH 2 OH; and

R k2 is C 1 -C 3 alkyl or CHF 2 .

13. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein Cy is

wherein R k2 is C 1 -C 3 alkyl or CHF 2 .

14. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein Cy is

wherein

R k1 is C 1 -C 6 alkyl or CH 2 CH 2 OH.

15. The compound of claim 8 or a pharmaceutically acceptable salt thereof, wherein R d1 is CF 3 .

16. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

17. A method of treating a disease or condition mediated by RORgammaT comprising administering a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof to a patient in need of such treatment, wherein the disease or condition is multiple sclerosis, inflammatory bowel disease, Crohn's disease, ankylosing spondylitis, psoriasis, rheumatoid arthritis, asthma, osteoarthritis, Kawasaki disease, Hashimoto's thyroiditis, or mucosal leishmaniasis.

18. The method of claim 17 , wherein the disease or condition is multiple sclerosis, inflammatory bowel disease, Crohn's disease, ankylosing spondylitis, psoriasis, rheumatoid arthritis, or asthma.

19. The method of claim 17 , wherein the disease or condition is ankylosing spondylitis or psoriasis.

20. The method of claim 19 , wherein the compound is a compound of claim 8 .

21. A compound selected from the following, or a pharmaceutically acceptable salt thereof:

(S)-ethyl 3-(4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(S)-ethyl 3-(6-((tert-butoxycarbonyl)amino)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(S)-3-((S)-4-((3-chloro-4-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R)-3-((S)-4-((3-chloro-4-fluorophenyl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-ethyl 3-(6-((tert-butoxycarbonyl)amino)-4-((4-fluoro-3-(trifluoromethyl)phenyl) sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(R)-ethyl 3-((S)-4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(S)-ethyl 3-((S)-4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(S)-ethyl 3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(R)-ethyl 3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(S)-ethyl 3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(R)-ethyl 3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoate;

(S)-ethyl 3-(4-((3-chloro-4-fluorophenyl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(S)-ethyl 3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl) sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(S)-ethyl 3-(4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate;

(S)-ethyl 3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoate

(S)-3-(4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-((S)-4-((3-chloro-4-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R)-3-((S)-4-((3-chloro-4-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-(4-((3-chloro-4-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R)-3-((S)-4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-((S)-4-((3-methoxy-1,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R)-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-(4-((3-cyanophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3,4-difluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-methoxy-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethoxy)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-(difluoromethoxy)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-chlorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-(m-tolylsulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-(methylsulfonyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((5-(trifluoromethyl)pyridin-3-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-methoxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-bromophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((1-(difluoromethyl)-3-ethoxy-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-chlorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2,3-dihydrobenzofuran-5-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-5-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-6-chloroimidazo[2,1-b]thiazole;

(S)-3-(4-((2-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3,4-dichlorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-chloro-2-fluorophenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-chloro-4-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-chloro-5-fluoro-2-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-2-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-5-chloropyridine;

(S)-3-(4-((4-chloro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((5-chloro-2-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-chloro-5-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-methoxy-5-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-methoxy-4-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-4-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-1-(2,2-difluoroethyl)-3-ethoxy-1H-pyrazole;

(S)-4-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-3-(2,2-difluoroethoxy)-1-ethyl-1H-pyrazole;

(S)-3-(4-((3-fluoro-5-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3,5-bis(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-4-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-2-methoxypyridine;

(S)-3-(4-((2,4-difluoro-5-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-4-((2-(2-carboxyethyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-2H-benzo[b][1,4]oxazin-4(3H)-yl)sulfonyl)-1-(difluoromethyl)-3-methyl-1H-pyrazole;

(S)-3-(4-((2-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((4-fluoro-3,5-dimethylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((2-chloro-4-fluoro-5-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-(difluoromethoxy)-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-[(2S)-4-{[3-(pentafluoro-lambda˜6˜-sulfanyl)phenyl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

(R or S)-3-((S)-4-((3-chloro-1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((3-chloro-1-cyclopropyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((1-(difluoromethyl)-3-methyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((1-(difluoromethyl)-3-ethoxy-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((3-(difluoromethoxy)-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((1-(2,2-difluoroethyl)-3-ethoxy-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((3-(2,2-difluoroethoxy)-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-methoxy-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-methoxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((5-ethoxy-2-ethylthiazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-cyclopropyl-5-ethoxythiazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-ethyl-5-isopropoxythiazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((2-ethyl-5-(2,2,2-trifluoroethoxy)thiazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S)-3-(4-((3-chloro-1-isopropyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-(4-((3-chloro-1-cyclopropyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-[(2S)-4-[(5-bromopyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(5-cyclopropylpyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-4-{[6-(trifluoromethyl)pyridin-2-yl]sulfonyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(5-methylpyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(5-methoxypyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(3-cyclopropyl-4-fluorophenyl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-(4-{[1-ethyl-3-(2-hydroxyethoxy)-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propanoic acid;

3-(4-[(3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl)propanoic acid;

3-[(2S)-4-[(5-ethoxy-2-ethyl-1,3-thiazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(2-cyclopropyl-5-ethoxy-1,3-thiazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-{[5-ethoxy-2-(trifluoromethyl)-1,3-thiazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-{[2-ethyl-5-(1-methylethoxy)-1,3-thiazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-{[2-ethyl-5-(2,2,2-trifluoroethoxy)-1,3-thiazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(5-cyclopropyl-2-fluorophenyl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

(S or R)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-2-methyl-3-((S)-4-(m-tolylsulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((3-(difluoromethoxy)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((3-(difluoromethoxy)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-2-methyl-3-((S)-4-(m-tolylsulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethoxy)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethoxy)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-3-((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-3-((S)-4-((3-cyclopropylphenyl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(S or R)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((5-(trifluoromethyl)pyridin-3-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((2-(trifluoromethyl)pyridin-4-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-3-((S)-4-((2-cyclopropylpyridin-4-yl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R or S)-3-((S)-4-((3-chloro-1-(difluoromethyl)-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-methylpropanoic acid;

(R)-2-(((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(S)-2-(((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(S)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-cyclopropylpropanoic acid;

(R)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-cyclopropylpropanoic acid;

(R or S)-2-(((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((1-ethyl-3-(2-hydroxyethoxy)-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-4-((1-ethyl-3-(2-hydroxyethoxy)-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(R or S)-2-(((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((2-(trifluoromethyl)pyridin-4-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)butanoic acid;

(S or R)-2-cyclopropyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-2-cyclopropyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-2-cyclopropyl-3-((S)-4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-2-cyclopropyl-3-((S)-4-((1-ethyl-3-(2-hydroxyethoxy)-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-2,2-dimethyl-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R)-3-(4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(R)-3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(R)-3-(4-((3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(R)-3-(4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(S)-3-(4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(S)-3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(S)-3-(4-((3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(S)-3-(4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(R)-3-(4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(S)-3-(4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

(R)-2,2-dimethyl-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((5-(trifluoromethyl)pyridin-3-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-2,2-dimethyl-3-(6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((5-(trifluoromethyl)pyridin-3-yl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-[(2S)-4-[(5-cyanopyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1, 1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(3-chloro-1-cyclopropyl-1H-pyrazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[1-(difluoromethyl)-3-methyl-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(5-ethoxy-2-ethyl-1,3-thiazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(2-cyclopropyl-5-ethoxy-1,3-thiazol-4-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[2-ethyl-5-(2,2,2-trifluoroethoxy)-1,3-thiazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[2-ethyl-5-(1-methylethoxy)-1,3-thiazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[3-chloro-1-(1-methylethyl)-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[1-(difluoromethyl)-3-ethoxy-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[3-(difluoromethoxy)-1-ethyl-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[1-(2,2-difluoroethyl)-3-ethoxy-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-{[3-(2,2-difluoroethoxy)-1-ethyl-1H-pyrazol-4-yl]sulfonyl}-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(2-chloro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(2-methoxy-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S)-4-[(2-methoxy-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid; (S)-1-((6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(R)-1-((6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(S)-1-((4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(S)-1-((4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(R)-1-((4-((4-fluoro-3-methylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(R)-1-((4-((3-cyclopropylphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(S)-1-((4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(R)-1-((4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(S)-1-((4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(R)-1-((4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)cyclopropanecarboxylic acid;

(S and R)-2-hydroxy-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxy-2-methylpropanoic acid;

(R)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxy-2-methylpropanoic acid;

(S)-3-hydroxy-2-methyl-2-(S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)propanoic acid;

(R)-3-hydroxy-2-methyl-2-(((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)propanoic acid;

(R or S)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxy-2-methylpropanoic acid;

(R or S)-2-hydroxy-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R or S)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxy-2-methylpropanoic acid;

(R and S)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxypropanoic acid;

(R or S)-2-hydroxy-2-methyl-3-((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(R and S)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-hydroxypropanoic acid;

(S or R)-3-hydroxy-2-methyl-2-(((S)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)methyl)propanoic acid;

(S or R)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-(hydroxymethyl)-2-methylpropanoic acid;

(S or R)-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2-(hydroxymethyl)-2-methylpropanoic acid;

(R)-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)butanoic acid;

(S)-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)butanoic acid;

(R)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-3-cyclopropylpropanoic acid;

(S)-3-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-3-cyclopropylpropanoic acid;

(S or R)-3-cyclopropyl-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-3-cyclopropyl-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-3-cyclopropyl-3-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(S or R)-3-cyclopropyl-3-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

(1R,2S)-2-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2R)-2-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2R)-2-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2S)-2-((S)-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2S)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2R)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2R)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2S)-2-((S)-4-tosyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2S)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2R)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2S)-2-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1R,2R)-2-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2S)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2R)-2-((S)-4-((4-fluoro-3-methoxyphenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1 S,2S)-2-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl) sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

(1S,2R)-2-((S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)cyclopropanecarboxylic acid;

3-((S)-4-((4-fluoro-3-methoxyphenyl) sulfonyl)-6-(((((S)-1,1,1-trifluoro-3,3-dimethylbutan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-((S)-4-((4-fluoro-3-methoxyphenyl) sulfonyl)-6-(((((R)-1,1,1-trifluoro-3,3-dimethylbutan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-{(2S)-4-[(4-fluoro-3-methoxyphenyl) sulfonyl]-6-[({[1-(trifluoromethyl)cyclopropyl]methoxy}carbonyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid;

3-{(2S)-4-[(4-fluoro-3-methoxyphenyl) sulfonyl]-6-[({[1-(trifluoromethyl)cyclobutyl]oxy}carbonyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid;

3-{(2S)-4-[(4-fluoro-3-methoxyphenyl)sulfonyl]-6-[({[(1S or 1R)-1,2,2-trimethylpropyl]oxy}carbonyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid;

3-{(2S)-4-[(4-fluoro-3-methoxyphenyl) sulfonyl]-6-[({[1-(trifluoromethyl)cyclohexyl]oxy}carbonyl)amino]-3,4-dihydro-2H-1,4-benzoxazin-2-yl}propanoic acid;

3-((S)-4-((4-fluoro-3-methoxyphenyl) sulfonyl)-6-(((((R and S)-1,1,1-trifluoro-2-methylbutan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-((2S,3R)-3-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-4-((3-(trifluoromethyl)phenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-((2S,3S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-3-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

3-((2S,3R)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-3-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

3-((2R,3R)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-3-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

3-((2R,3S)-4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-3-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid;

3-[(2R,3S)-4-[(4-fluoro-3-methoxyphenyl) sulfonyl]-3-methyl-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

3-[(2S,3R)-4-[(4-fluoro-3-methoxyphenyl) sulfonyl]-3-methyl-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]-2,2-dimethylpropanoic acid;

(S)-3-(8-fluoro-4-((4-fluoro-3-(trifluoromethyl)phenyl)sulfonyl)-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)propanoic acid;

3-[(2S)-8-fluoro-4-[(4-fluoro-3-methylphenyl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-8-fluoro-4-[(4-fluoro-3-methoxyphenyl)sulfonyl]-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl]-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(3-ethoxy-1-ethyl-1H-pyrazol-4-yl)sulfonyl]-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-4-1 [3-(trifluoromethyl)phenyl]sulfonyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(3-chloro-4-fluorophenyl)sulfonyl]-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-4-[(3-cyclopropylphenyl)sulfonyl]-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-4-{[2-(trifluoromethyl)pyridin-4-yl]sulfonyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

3-[(2S)-8-fluoro-6-{[(2,2,2-trifluoro-1,1-dimethylethoxy)carbonyl]amino}-4-{[5-(trifluoromethyl)pyridin-3-yl]sulfonyl}-3,4-dihydro-2H-1,4-benzoxazin-2-yl]propanoic acid;

(R)-3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-5-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid; and

(S)-3-(4-((3-chloro-1-ethyl-1H-pyrazol-4-yl)sulfonyl)-5-methyl-6-((((1,1,1-trifluoro-2-methylpropan-2-yl)oxy)carbonyl)amino)-3,4-dihydro-2H-benzo[b][1,4]oxazin-2-yl)-2,2-dimethylpropanoic acid.

Assignments (4)

MERGER Recorded Aug 8, 2022

From: MERCK SHARP & DOHME CORP.

To: MERCK SHARP & DOHME LLC

Reel/Frame 061102/0145 →

SECURITY INTEREST Recorded Jan 3, 2019

From: LYCERA CORP.

To: WILMINGTON TRUST, NATIONAL ASSOCIATION

Reel/Frame 048002/0201 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2017

From: AICHER, THOMAS D.; VANHUIS, CHAD A.

To: LYCERA CORPORATION

Reel/Frame 042058/0659 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2017

From: MACLEAN, JOHN; ANDRESEN, BRIAN M.; BARR, KENNETH J.; BIENSTOCK, COREY; DANIELS, MATTHEW; LIU, KUN; LIU, YUAN; WHITE, CATHERINE; SCIAMMETTA, NUNZIO; SIMOV, VLADIMIR

To: MERCK SHARP & DOHME CORP.

Reel/Frame 042058/0684 →