IP Library › Patent Application 15103791
Patent Application
App. No. 15/103,791

CYANOACRYLATE COMPOSITIONS INCLUDING NON-AGGLOMERATING RADIOPAQUE NANOPARTICLES

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Patent No.
US None
App. No.
15/103,791
Abstract

Radiopaque medical cyanoacrylate compositions including a cyanoacrylate monomer; and a radiopacifier including nanoparticles having a mean size of less than about 15 nanometers (nm), wherein the nanoparticles do not substantially agglomerate within the composition at about 20 degrees Celsius (° C.), and wherein the composition has a viscosity of between about 1,000 centipoise (cP) and about 2,000 cP.

Claims (27)

1 : A radiopaque medical cyanoacrylate composition comprising:

a cyanoacrylate monomer; and

a radiopacifier comprising nanoparticles having a mean size of less than about 15 nanometers (nm), wherein the nanoparticles do not substantially agglomerate within the composition at about 20 degrees Celsius (° C.), and wherein the composition has a viscosity of between about 1,000 centipoise (cP) and about 2,000 cP.

2 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the nanoparticles comprise at least one of a metal, metal oxide, or alloy thereof.

3 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the nanoparticles comprise at least one of tantalum (Ta), tantalum oxide (TaO), gold (Au), platinum (Pt), zirconium (Zr), or zirconium oxide (ZrO).

4 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the nanoparticles have a mean size of less than about 10 nm.

5 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the nanoparticles have a mean size of less than about 5 nm and the nanoparticles comprise gold.

6 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the composition has a shelf life without the nanoparticles agglomerating in the composition of greater than about two weeks.

7 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the nanoparticles include a surface treatment configured to prevent surface oxidation.

8 : The radiopaque medical cyanoacrylate composition of claim 7 , wherein the surface treatment comprises a capping agent.

9 : The radiopaque medical cyanoacrylate composition of claim 1 , wherein the composition includes about 5 to about 50 volume percent nanoparticles.

10 : The radiopaque medical cyanoacrylate composition of claim 1 , further comprising:

a thickening agent; and

a polymerization inhibitor.

11 : A method of forming a radiopaque medical cyanoacrylate composition, the method comprising mixing a cyanoacrylate monomer and a radiopacifier comprising nanoparticles having a mean size of less than about 15 nanometers (nm), wherein the nanoparticles do not substantially agglomerate within the composition at about 20 degrees Celsius (° C.), and wherein the composition has a viscosity of between about 1,000 centipoise (cP) and about 2,000 cP.

12 : The method of claim 11 , wherein the nanoparticles comprise at least one of a metal, metal oxide, or alloy thereof.

13 : The method of claim 11 , wherein the nanoparticles comprise at least one of tantalum (Ta), tantalum oxide (TaO), gold (Au), platinum (Pt), zirconium (Zr), or zirconium oxide (ZrO).

14 : The method of claim 11 , wherein the nanoparticles have a mean size of less than about 10 nm.

15 : The method of claim 11 , wherein the nanoparticles have a mean size of less than about 5 nm and the nanoparticles comprise gold.

16 : The method of claim 11 , wherein the composition has a shelf life without the nanoparticles agglomerating in the composition of greater than about two weeks.

17 : The method of claim 11 , wherein the nanoparticles include a surface treatment configured to prevent surface oxidation.

18 : The method of claim 17 , wherein the surface treatment comprises a capping agent.

19 : The method of claim 11 , wherein the composition includes about 5 to about 50 volume percent nanoparticles.

20 : The method of claim 11 , wherein the composition includes a thickening agent and a polymerization inhibitor.

21 : A method of treating a patient, the method comprising injecting a radiopaque medical cyanoacrylate composition into a body lumen of a patient, the composition comprising a cyanoacrylate monomer and a radiopacifier comprising nanoparticles having a mean size of less than about 15 nm, wherein the nanoparticles do not substantially agglomerate within the composition at about 20 degrees Celsius (° C.), and wherein the composition has a viscosity of between about 1,000 centipoise (cP) and about 2,000 cP.

22 : The method of claim 21 , further comprising radiographic imaging the composition following injection into the body lumen of the patient.

23 : The method of claim 22 , wherein the body lumen comprises one of an artery or vein.