Composition for treating prostate cancer
The present invention relates to a composition for treating prostate cancer and, more specifically, to a composition for treating prostate cancer, which contains a peptide derived from telomerase and is effective in inhibiting growth and metastasis of prostate cancer cells. In addition, the present invention provides a composition and method for treating prostate cancer, wherein, when prostate cancer is treated, docetaxel and the peptide derived from telomerase are co-administered, thereby having a synergetic therapeutic effect compared with administration alone. Particularly, the present invention provides a treatment method useful for patients who do not have a sufficient anticancer effect merely through administration of docetaxel alone and patients who have hormone resistance.
1. A method of treating hormone-tolerant prostate cancer in a patient in need thereof comprising administering to the patient the isolated peptide of SEQ ID NO: 1 and an anti-cancer drug selected from docetaxel or leuprolide acetate, wherein tumor volume is decreased upon co-administration of the isolated peptide of SEQ ID NO: 1 with docetaxel or leuprolide acetate compared to administration of docetaxel or leuprolide acetate alone.
2. The method according to claim 1 , wherein the patient has at least one of eotaxin and MIP1α at a serum concentration of at least 10% higher than the average serum concentration in prostate cancer patients.
3. The method according to claim 1 , wherein the peptide is administered at a daily dose of 0.1 ng/kg to 10 mg/kg.
4. The method according to claim 1 , wherein the peptide is administered at a daily dose of 1 μg/kg to 100 μg/kg.
5. The method according to claim 1 , wherein the peptide is administered three times per week during the first week, followed by once per week during the second, third, fourth, and sixth week, and followed by once every four weeks thereafter.
6. The method according to claim 1 , wherein docetaxel is administered in a range of 60 mg/m 2 to 400 mg/m 2 .
7. The method according to claim 1 , wherein docetaxel is intravenously administered every three weeks in a range of 60 mg/m 2 to 100 mg/m 2 during one hour.
8. A method of treating hormone-tolerant prostate cancer in a patient in need thereof comprising administering to the patient a composition comprising the isolated peptide of SEQ ID NO: 1 and an anti-cancer drug selected from docetaxel or leuprolide acetate, wherein tumor volume is decreased upon co-administration of a composition comprising the isolated peptide of SEQ ID NO: 1 with docetaxel or leuprolide acetate compared to administration of docetaxel or leuprolide acetate alone.
9. The method according to claim 8 , wherein the patient has at least one of eotaxin and MIP1α at a serum concentration of at least 10% higher compared to their average serum concentration in prostate cancer patients.
10. The method according to claim 8 , wherein the composition is administered through an oral, rectal, transdermal, intravenous, intramuscular, intraperitoneal, in the bone marrow, epidural, or subcutaneous route.
11. The method of claim 8 , wherein the composition comprises 0.01 g/L to 1 kg/L of the isolated peptide.
12. The method of claim 8 , wherein the peptide is administered at a daily dose of 0.1 ng/kg to 10 mg/kg.
13. The method according to claim 8 , wherein the peptide is administered at a daily dose of 1 μg/kg to 100 μg/kg.
14. The method according to claim 8 , wherein the composition is administered three times per week during the first week, followed by once per week during the second, third, fourth, and sixth week, and followed by once every four weeks thereafter.
15. The method according to claim 8 , wherein docetaxel is administered in a range of 60 mg/m 2 to 400 mg/m 2 .
16. The method according to claim 8 , wherein docetaxel is intravenously administered every three weeks in a range of 60 mg/m 2 to 100 mg/m 2 during one hour.