IP Library › Granted Patent US 10,526,392
Granted Patent B2
US 10,526,392 · App. 15/110,057 · Granted Jan 7, 2020

Synthetic biology-based ADCC technology

Inventors: Chiang J. Li (Cambridge, MA); Shyam Unniraman (Newton, MA)
Assignee: 1GLOBE BIOMEDICAL CO., LTD.
C07K14/70535A61K35/17C07K14/7051C07K14/70503C07K14/70521C07K14/70575C07K14/70578C07K14/7153A61K48/005C07K2319/03C07K2319/70
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Quick Facts
Patent No.
US 10,526,392
App. No.
15/110,057
Granted
Jan 7, 2020
Kind
B2
Abstract

A novel synthetic biology-based ADCC technology is provided that enhances or enables ADCC response. The novel ADCC technology can be used to prevent or treat cancers, infectious, inflammatory or autoimmune diseases, and other diseases where elimination of diseased cells is desirable.

Claims (3)

1. A genetic construct that encodes a transmembrane chimeric receptor, comprising a DNA sequence selected from the group consisting of SEQ ID NOs:1, 3, 5, 7, and 9.

2. The genetic construct of claim 1 , wherein the encoded transmembrane chimeric receptor comprises the sequence of SEQ ID NO: 2 or the sequence of SEQ ID NO: 10.

3. The genetic construct of claim 1 , comprising SEQ ID NO: 9.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 4, 2019
From: 1GLOBE HEALTH INSTITUTE LLC
To: 1GLOBE BIOMEDICAL CO., LTD.
Reel/Frame 048235/0290 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 29, 2018
From: LI, CHIANG J.; UNNIRAMAN, SHYAM
To: 1GLOBE HEALTH INSTITUTE LLC
Reel/Frame 046744/0470 →
Continuity (2)
Provisional Application 61925217 · Jan 8, 2014
Related Publication 20160355566A1 · Dec 8, 2016