IP Library Granted Patent US 9,733,460
Granted Patent B2
US 9,733,460 · App. 15/110,388 · Granted Aug 15, 2017

Method and apparatus for microscopic imaging

Inventors: Dongkyun Kang (Somerville, MA); Minkyu Kim (Boston, MA); Guillermo J. Tearney (Cambridge, MA)
Assignee: The General Hospital Corporation
G02B21/0008A61B3/1025A61B5/0068A61B5/6898G02B21/0028G02B21/0064H04M1/215A61B5/0066A61B5/0084A61B2560/045G01N21/4795G02B23/2453
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Quick Facts
Patent No.
US 9,733,460
App. No.
15/110,388
Granted
Aug 15, 2017
Kind
B2
Abstract

Apparatus and method for facilitating a microscopic imaging of at least one anatomical structure can be provided. For example, with a spectrally-encoded confocal microscopy (SECM) system, it is possible to provide at least one first electro-magnetic radiation to the anatomical structure(s). In addition, a mobile device can be provided which can communicate with the SECM system. The mobile device can have a sensor arrangement, and with such sensor arrangement, it is possible to receive at least one second electro-magnetic radiation that is based on the first radiation(s) from at least one section of the SECM system. The mobile device can further include a computer arrangement, with which it is possible to display at least one portion of the anatomical structure(s) as a microscopic image based on the second radiation(s) received by the sensor arrangement.

Claims (33)

1. An apparatus for facilitating a microscopic imaging of at least one anatomical structure, comprising:

a spectrally-encoded confocal microscopy (SECM) system configured to provide at least one first electro-magnetic radiation to the at least one anatomical structure; and

a mobile device communicating with the SECM system, and including a sensor arrangement that is configured to receive at least one second electro-magnetic radiation that is based on the at least one first electro-magentic radiation from at least one section of the SECM system, the mobile device further including a computer arrangement which is configured to display at least one portion of the at least one anatomical structure as a microscopic image based on the at least one second radiation received by the sensor arrangement,

wherein the at least one first electro-magnetic radiation is originated from a radiation source residing in the mobile device.

2. The apparatus according to claim 1 , wherein the microscopic image is a confocal image of the at least one portion.

3. The apparatus according to claim 1 , wherein the SECM system includes an optical arrangement which facilitates a motionless scan of the at least one anatomical structure via the at least one first electro-magnetic radiation.

4. The apparatus according to claim 1 , wherein the SECM system includes a relay optical arrangement which facilitates a transmission of the at least one second radiation to the sensor arrangement.

5. The apparatus according to claim 1 , wherein the SECM system includes an internal energy storage arrangement.

6. The apparatus according to claim 1 , further comprising a waveguide arrangement provided between the SECM system and the at least one anatomical structure.

7. The apparatus according to claim 6 , wherein the waveguide arrangement is configured to (i) forward the at least one first electro-magnetic radiation to the at least one anatomical structure, and (ii) receive the at least one second electro-magnetic radiation from the at least one anatomical structure.

8. The apparatus according to claim 1 , further comprising first and second waveguide arrangements provided between the SECM system and the at least one anatomical structure.

9. The apparatus according to claim 8 , wherein the first waveguide arrangement is configured to forward the at least one first electro-magnetic radiation to the at least one anatomical structure, and the second waveguide arrangement is configured to receive the at least one second electro-magnetic radiation from the at least one anatomical structure.

10. The apparatus according to claim 1 , wherein the SECM system comprises an optical configuration that focuses the at least one first electro-magnetic radiation toward the at least one anatomical structure.

11. The apparatus according to claim 1 , wherein the SECM system comprises an optical configuration that focuses the at least one first electro-magnetic radiation directly unto the at least one anatomical structure.

12. A method for facilitating a microscopic imaging of at least one anatomical structure, comprising:

with a spectrally-encoded confocal microscopy (SECM) system, providing at least one first electro-magnetic radiation to the at least one anatomical structure;

with a sensor arrangement of a mobile device, receiving at least one second electro-magnetic radiation that is based on the at least one first electro-magnetic radiation from at least one section of the SECM system; and

with a computer arrangement of the mobile device, displaying at least one portion of the at least one anatomical structure as a microscopic image based on the at least one second radiation received by the sensor arrangement,

wherein the at least one first electro-magnetic radiation is originated from a radiation source residing in the mobile device.

13. The method according to claim 12 , wherein the microscopic image is a confocal image of the at least one portion.

14. The method according to claim 12 , further comprising, with an optical arrangement of the SECM system, facilitating a motionless scan of the at least one anatomical structure via the at least one first electro-magnetic radiation.

15. The method according to claim 12 , further comprising, with a relay optical arrangement of the SECM system, facilitating a transmission of the at least one second radiation to the sensor arrangement.

16. The method according to claim 12 , wherein the SECM system includes an internal energy storage arrangement.

17. The method according to claim 12 , wherein a waveguide arrangement is provided between the SECM system and the at least one anatomical structure.

18. The method according to claim 17 , further comprising, with the waveguide arrangement:

forwarding the at least one first electro-magnetic radiation to the at least one anatomical structure; and

receiving the at least one second electro-magnetic radiation from the at least one anatomical structure.

19. The method according to claim 12 , wherein first and second waveguide arrangements are provided between the SECM system and the at least one anatomical structure.

20. The method according to claim 19 , further comprising:

with the first waveguide arrangement, forwarding the at least one first electro-magnetic radiation to the at least one anatomical structure; and

with the second waveguide arrangement, receiving the at least one second electro-magnetic radiation from the at least one anatomical structure.

21. The method according to claim 12 , wherein the providing procedure is performed using an optical configuration of the SECM system by focusing the at least one first electro-magnetic radiation toward the at least one anatomical structure.

22. The method according to claim 12 , wherein the providing procedure is performed using an optical configuration of the SECM system by focusing the at least one first electro-magnetic radiation directly unto the at least one anatomical structure.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 19, 2022
From: MASSACHUSETTS GENERAL HOSPITAL
To: THE GOVERNMENT OF THE UNITED STATES AS REPRESENTED BY THE SECRETARY OF THE ARMY
Reel/Frame 058691/0617 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2017
From: KANG, DONGKYUN; KIM, MINKYU; TEARNEY, GUILLERMO J.
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 042001/0179 →
Continuity (2)
Provisional Application 61924790 · Jan 8, 2014
Related Publication 20160334610A1 · Nov 17, 2016