Crystalline forms of dolutegravir sodium
The present disclosure relates to novel crystalline dolutegravir sodium Form-M2, Form-M3, Form-M4 and process for the preparation thereof.
1. A crystalline dolutegravir sodium Form-M2, which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 6.23, 7.87, 19.54, 21.34 and 23.84 ±0.2°.
2. The crystalline dolutegravir sodium Form-M2 according to claim 1 which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 6.23, 7.87, 9.80, 12.46, 12.69, 12.88, 15.15, 16.28, 16.94, 17.91, 18.42, 18.74, 19.06, 19.54, 19.75, 20.25, 21.34, 21.82, 23.84, 24.36, 24.81, 25.02, 25.32, 25.51, 26.17, 27.17, 28.14, 28.82, 29.31, 29.75, 31.25, 31.52, 32.05 and 32.82±0.2°.
3. A crystalline dolutegravir sodium Form-M2, which has a powder X-ray diffraction pattern as shown in FIG. 1 .
4. A process for the preparation of crystalline dolutegravir sodium Form-M2 comprising the steps of:
a. dissolving dolutegravir in an organic solvent at elevated temperature;
b. adding alcoholic sodium hydroxide solution; and
c. isolating crystalline dolutegravir sodium Form-M2.
5. The process of claim 4 , wherein organic solvent is a polar protic solvent.
6. The process of claim 5 , wherein the polar protic solvent is selected from the group consisting of methanol, ethanol, isopropanol, 1-butanol, 2-butanol, isoamyl alcohol, isobutyl alcohol, 1-pentanol, 1-propanol, 2-prapanol and mixtures thereof and alcoholic sodium hydroxide is selected from methanolic sodium hydroxide, ethanolic sodium hydroxide, isopropanol sodium hydroxide and mixtures thereof.
7. A crystalline dolutegravir sodium Form-M3, which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 5.91, 13.98, 17.51, 19.63 and 22.31 ±0.2°.
8. A crystalline dolutegravir sodium Form-M3, according to claim 7 which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 5.91, 8.38, 9.32, 13.06, 13.98, 15.02, 16.42, 17.51, 18.03, 18.75, 19.63, 20.73, 21.70, 22.31, 23.52, 25.06, 25.45, 26.19, 26.72, 27.51, 29.45, 31.69, 34.28, 38.36 and 45.56±0.2°.
9. A crystalline dolutegravir sodium Form-M3, which has a powder X-ray diffraction pattern as shown in FIG. 2 .
10. A process for the preparation of crystalline dolutegravir sodium Form-M3 comprising the step of drying dolutegravir sodium Form-M2 under reduced pressure at a temperature of 75-85° C. for 12-15 hours.
11. A crystalline dolutegravir sodium Form-M4, which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 8.10, 18.40, 19.19, 21.23, 21.72 and 24.02 ±0.2°.
12. A crystalline dolutegravir sodium Form-M4, according to claim 11 which has a powder X-ray diffraction pattern having 2Θ angle of significant peaks at about 6.34, 8.10, 11.82, 12.93, 14.43, 15.63, 16.52, 17.46, 18.40, 19.19, 19.41, 20.09, 21.23, 21.72, 22.27, 24.02, 24.90, 25.65, 27.59, 28.44, 29.70, 30.81, 34.11, 35.54, 38.36 and 46.35±0.2°.
13. A crystalline dolutegravir sodium Form-M4, which has a powder X-ray diffraction pattern as shown in FIG. 3 .
14. A process for the preparation of crystalline dolutegravir sodium Form-M4 comprising the step of drying dolutegravir sodium Form-M3 or Form-M2 under reduced pressure at a temperature of 70-140° C. for 15-48 hours.
15. A process for the preparation of crystalline dolutegravir sodium Form-M4 comprising the step of drying dolutegravir sodium Form-M3 or Form-M2 at a temperature of 190-210° C. for 15-20 minutes.