Time-dependent synthetic biological barrier material
Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed to yield a stabilizing effect without altering morphological properties of a first fiber system. By addition of a stabilizing fiber population one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state. In one particular abstract, medical barrier materials may be formed from the electrospun materials to provide improved medical barriers for treatments.
1. A thermally stable electrospun barrier comprising: two independent fiber populations;
a major fiber population comprising at least one thermally unstable fiber species, wherein the thermally unstable fiber species comprises polymers or copolymers that are degradable by hydrolysis or other biodegradation mechanisms; are derived from cyclic monomers selected from the group consisting of glycolide, lactide, caprolactone, para-dioxanone, trimethylene carbonate, and mixtures thereof;
a minor fiber population comprising at least one thermally stable fiber species, wherein the thermally stable fiber species comprises polymers or copolymers selected from polyesters, polyethers, polyester-carbonates, polyether-ester or copolymers thereof, a block copolymer having one or more blocks of polydioxanone (PDO), co-polymers comprised of polymers where the majority of the polymer is comprised of PDO, poly(E-caprolactone) and its copolymers, poly(L-lactic acid), poly(ethylene terephthalate), polyethylene, polypropylene, a nylon, polyurethanes, or PEEK;
wherein the major and minor fiber populations are co-mingled and distributed throughout the electrospun barrier;
wherein each fiber population does not comprise a composite fiber wherein neither a polymer or copolymer forming a thermally stable fiber species is present in a thermally unstable fiber species, nor is a polymer or copolymer forming a thermally unstable fiber species present in a thermally stable fiber species;
wherein the thermally stable species comprises 13 wt % to up to 49 wt % percent of the thermally stable electrospun material;
wherein each fiber population is dispensed from a spinneret separate from the spinneret of another fiber population so that none of the thermally stable fiber species are present in the population of the thermally stable fiber population and none of the thermally unstable fiber species are present in the thermally unstable fiber population; and
wherein the electrospun barrier is dimensionally stable up to 5.0° C. and under these temperature conditions, will not decrease in size by more than 10 percent.
2. The thermally stable electrospun barrier of claim 1 ,
wherein the major fiber population is absorbable.
3. The thermally stable electrospun barrier of claim 1 , wherein the minor fiber population has a higher crystallization temperature than the major fiber population.
4. The thermally stable electrospun barrier of claim 3 , wherein the major fiber population has a crystallization temperature in the range of 50 to 80° C. and the minor fiber population has a crystallization temperature in the range of 100-140° C.
5. The thermally stable electrospun barrier of claim 1 , wherein porosity is 75% or greater.
6. The thermally stable electrospun barrier of claim 1 , wherein porosity of the thermally stable electrospun barrier increases as the major fiber population is absorbed.
7. The thermally stable electrospun barrier of claim 1 , wherein the major fiber population is an absorbable copolymer of glycolide and lactide.
8. The thermally stable electrospun barrier of claim 7 , wherein the major fiber population is an absorbable PGLA copolymer with a monomer ratio of glycolide to lactide of about 90:10.
9. The thermally stable electrospun barrier of claim 1 , wherein the minor fiber population is nonabsorbable.
10. The thermally stable electrospun barrier of claim 9 , wherein the nonabsorbable fiber is poly(ethylene terephthalate).