Systems, apparatuses and methods for determining blood pressure

1. A continuous blood pressure measuring apparatus for measuring time-varying radar cross section (RCS) of an artery of a patient so as to determine blood pressure of the patient, comprising:

a radio-frequency (RF) transceiver for generating RF waves;

at least one RF sensor configured for positioning on or adjacent the skin of a patient, and continuously transmit the RF waves into tissue of the patient and continuously receiving RF wave reflections from at least one artery located within the tissue;

at least one ECG sensor configured for:

positioning on the patient's body, and

continuously receiving ECG signals corresponding to an ECG waveform of the patient, and

a processor having computer instructions operating thereon configured to cause the processor to continuously:

determine an RF arterial pulse waveform based on the received RF wave reflections, wherein the time-varying radar cross section (RCS) comprises the RF arterial pulse waveform,

correlate the time-varying RCS to a time-varying diameter of the at least one artery,

synchronize the ECG signals with the RF wave reflections from the at least one artery located within the tissue,

determine, based on the time-varying RCS and the synchronization, a pre-ejection period (PEP) indicating a time lapse between a ventricular polarization as indicated by the ECG signals and an opening of aortic value of the patient as indicated by the time-varying RCS, and

determine values of systolic blood pressure (SBP) and diastolic blood pressure (DBP), based on:

the time-varying RCS, and

the PEP, the PEP having been determined on the time-varying RCS and the synchronization.

2. The apparatus of claim 1 , wherein the at least one RF sensor comprises at least one antennae, and/or the at least one RF sensor is configured with flexibility to enable the at least one RF sensor to conform to the skin of the patient.

3. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to condition the RF arterial pulse waveform using at least one radar echo from a specific range.

4. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to condition the RF arterial pulse waveform using band pass filtering.

5. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to characterize the RF arterial pulse waveform including one or more characteristics selected from the group consisting of:

a peak-to-peak amplitude of the RF arterial pulse waveform,

a time location of at least one of a peak of the RF arterial pulse waveform,

a first derivative peak, and one or more additional points marking an RF-arterial-pulse-arrive-time (RF-PAT), and

a timing of a dicrotic notch of the RF arterial pulse waveform.

6. The apparatus of claim 1 , wherein

the at least one RF sensor is positioned to receive the RF wave reflections from the aorta of the patient, and

the computer instructions are additionally configured to cause the processor to determine an R-peak of the ECG waveform.

7. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to determine an arterial-pulse-travel-time (PTT) by subtracting the PEP from PAT.

8. The apparatus of claim 7 , wherein the SBP and the DBP are determined based on the PTT and calibrated for each patient.

9. The apparatus of 8 , wherein calibration comprises determining coefficients corresponding to determining the SBP and the DBP.

10. The apparatus of claim 1 , wherein the at least one RF sensor is configured for sensing the RF wave reflections corresponding to an arterial-pulse-arrival-time (PAT) to each of two different arterial tree locations, the two different arterial tree locations discerned based on depth resolution of the tissue.

11. The apparatus of claim 1 , wherein the at least one RF sensor is configured for sensing the RF wave reflections corresponding to an arterial-pulse-arrival-time (PAT) to each of two different arterial tree locations, wherein the computer instructions are additionally configured to cause the processor to determine an arterial-pulse-travel-time (PTT) by determining a difference between the PAT at the two different arterial tree locations.

12. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to determine an arterial pulse-wave velocity (PWV), wherein the PWV equals a propagation distance of the arterial pulse wave divided by pulse travel time (PTT).

13. The apparatus of claim 1 , wherein the computer instructions are further configured to cause the processor to synchronize the ECG signals with the RF wave reflections from the at least one artery located within the tissue based at least in part on a timing associated with one or more R peaks in the ECG signals.

14. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to determine a pulse-arrival-time (PAT) based on a time difference between an RF-arterial-pulse-arrive-time (RF-PAT) and an R-peak of the ECG waveform.

15. The apparatus of claim 1 , wherein the computer instructions are additionally configured to cause the processor to output the SBP and DBP.

16. A continuous blood pressure measuring method for measuring a time-varying radar cross section (RCS) of at least one an artery within a tissue of a patient so as to determine blood pressure of the patient, comprising:

positioning at least one ECG sensor and at least one RF sensor on the patient's body, and

continuously:

transmitting RF waves into the tissue at a first location via the at least one RF sensor;

receiving RF wave reflections from the at least one artery via at least one RF sensor;

receiving ECG signals corresponding to an ECG waveform of the patient via the at least one ECG sensor,

synchronizing the ECG signals with the RF wave reflections from the at least one artery located within the tissue; and

determining an RF arterial pulse waveform based on the received RF wave reflections, wherein the RF arterial pulse waveform corresponds to the time-varying (RCS) of the at least one artery;

determining, based on the time-varying RCS and the synchronization, a pre-ejection period (PEP) indicating a time lapse between a ventricular polarization as indicated by the ECG signals and an opening of aortic value of the patient as indicated by the time-varying RCS,

conditioning the RF arterial pulse waveform using at least one radar echo from a specific range adapted to the at least one artery; and

determining values of systolic blood pressure (SBP) and diastolic blood pressure (DBP), based on:

the time varying RCS, and

the PEP, the PEP having been determined on the time-varying RCS and the synchronization.

17. The method of claim 16 , wherein the at least one RF sensor comprises a first RF sensor and a second RF sensor, the method further comprising:

sensing, via the first RF sensor, RF wave reflections corresponding to an arterial-pulse-arrival-time (PAT) at a first arterial tree location,

sensing, via the second RF sensor, signals corresponding to PAT at a second arterial tree location,

determining the PAT at each location, and

determining the difference between the PAT at the two locations so as to determine the an arterial-pulse-travel-time (PTT).

18. The method of claim 17 , further comprising determining a timing of a dicrotic notch of the RF arterial pulse waveform.

19. The method of claim 16 , further comprising determining a timing of a dicrotic notch of the RF arterial pulse waveform.

20. The method of claim 16 , wherein synchronizing the ECG signals with the RF wave reflections from the at least one artery located within the tissue is based at least in part on a timing associated with one or more R peaks in the ECG signals.

21. The method of claim 16 , further comprising determining a pulse-arrival-time (PAT) based on a time difference between an RF-arterial-pulse-arrive-time (RF-PAT) and an R-peak of the ECG waveform.

22. The method of claim 16 , further comprising outputting the SBP and DBP.

23. The method of claim 16 , further comprising determining an arterial-pulse-travel-time (PTT) by subtracting the PEP from PAT.

24. The method of claim 23 , wherein the SBP and the DBP are determined based on the PTT and calibrated for each patient.

25. The method of 24 , wherein calibration comprises determining coefficients corresponding to each of the SBP and the DBP.