Compositions and methods relating to the treatment of diseases
The present invention relates to compositions and methods for promoting the induction of a cell-mediated immune response (such as that mediated by Th1 cells) and the suppression of a humoral or allergic immune response (such as that mediated by Th2 and Th17 cells). In particular, the invention relates to compositions and methods for preventing or treating allergy, such as food allergy, and associated allergic diseases, and conditions where an exaggerated Th17 response plays a detrimental role. The invention further extends to the use of the compositions of the invention in the treatment and/or prophylaxis of allergy and associated allergic diseases and also of cancer.
1. A method for the treatment of a condition where an enhancement of a Th1-mediated immune response and suppression of a Th2/Th17-mediated immune response are desired, and wherein the condition is cancer, said method comprising the step of:
(i) administering to a subject in need thereof a therapeutically effective amount of a hybrid of IFN-α10 and IFN-α14, wherein the hybrid includes the primary interferon receptor binding sites of IFN-α10 and IFN-α14 and has improved binding to interferon receptor 1 and interferon receptor 2 in comparison to IFN-α10 or IFN-α14, and wherein the hybrid comprises the amino acid sequence set forth by SEQ ID NO: 1.
2. The method as claimed in claim 1 wherein the cancer is hepatic cell cancer, lung cancer, non-small cell lung cancer, ovarian cancer, breast cancer, skin cancer, melanoma, genitourinary cancer, prostate cancer, renal cell cancer, or bladder cancer.
3. The method as claimed in claim 1 wherein the hybrid of IFN-α10 and IFN-α14 is administered orally.
4. The method as claimed in claim 1 wherein the method includes a step of administering to the subject a therapeutically effective amount of a vaccine composition for treatment of the condition where an enhancement of a Th1-mediated immune response and suppression of a Th2/Th17-mediated immune response are desired.
5. The method as claimed in claim 4 wherein the vaccine composition comprises at least one allergen capable of mediating a Th2/Th17 immune response.
6. The method as claimed in claim 5 wherein the at least one allergen is a tumour antigen.
7. The method as claimed in claim 4 wherein the vaccine composition is administered sequentially, separately or simultaneously with the at least one interferon alpha subtype.