Fractionated radiotherapy and chemotherapy with an oxygen therapeutic
A fluorocarbon emulsion in water for use in fractionated radiotherapy and chemotherapy, wherein said fluorocarbon comprises between 4 and 8 carbon atoms.
1. A method of sensitizing a mammal to multi-fraction radiotherapy or chemotherapy, comprising
concomitantly or up to 120 minutes prior to each fraction of radiation therapy or concomitantly with chemotherapy, administering a water emulsion of perfluoropentane to the mammal, wherein the perfluoropentane emulsion comprises a phospholipid, a viscosity modifier, a fluorosurfactant, and about 1% to 5% w/vol of perfluoropentane; and
simultaneously administering to said mammal carbogen or supplemental oxygen,
wherein the perfluoropentane emulsion is administered at a dosage in the range from about 0.05 cc/kg to about 0.3 cc/kg.
2. The method of claim 1 , wherein the perfluoropentane emulsion comprises about 2% w/vol of perfluoropentane.
3. The method of claim 1 , wherein administration of the perfluoropentane emulsion is intravenous infusion for up to 30 minutes.
4. The method of claim 1 , wherein administration of the perfluoropentane emulsion is intravenous infusion as a single bolus.
5. The method of claim 1 , wherein the fluorosurfactant is PEG Telomer B.
6. The method of claim 5 , wherein said viscosity modifier comprises sucrose.
7. The method of claim 6 , wherein said sucrose is present at about 300 mg/mL.
8. The method of claim 5 , wherein said fluorosurfactant is PEG Telomer B is present at about 3 mg/mL.
9. The method of claim 1 , wherein the perfluoropentane emulsion is co-administered with an anticancer agent.
10. The method of claim 9 , wherein said anticancer agent is an antibody.