Vaccine delivery systems using yeast cell wall particles
The present invention generally relates to compositions and methods for delivering a vaccine. The compositions and methods disclosed herein are particularly useful in making prophylactic and therapeutic vaccines.
1. A method for treating cancer, comprising administering to a subject a composition comprising (i) a yeast cell wall particle; (ii) a silicate, and (iii) an exogenous biological material loaded within the particle, wherein the biological material comprises a tumor lysate, and wherein the yeast cell wall particle is coated with the silicate.
2. The method of claim 1 , wherein the cancer is selected from the group consisting of breast cancer, small cell lung cancer, non-small cell lung cancer, glioma, medulloblastoma, neuroblastoma, Wilms tumors, rhabdomyosarcoma, osteosarcoma, liver cancer, pancreatic cancer, melanoma, prostate cancer and ocular melanoma.
3. The method of claim 1 , wherein the silicate is selected from the group consisting of tetraethylorthosilicate, tetramethylorthosilicate, tetrapropylorthosilicate, and tetrabutylorthosilicate.
4. The method of claim 1 , wherein the biological material loaded particle is further incubated with an isolated dendritic cell prior to administration.
5. The method of claim 1 , wherein the composition further comprises one or more adjuvants, excipients, and preservatives.
6. The method of claim 5 , wherein the adjuvant is monophosphoryl lipid A or a CpG oligonucleotide.
7. The method of claim 5 , wherein the one or more adjuvants are loaded within the yeast cell wall particle.