IP Library › Granted Patent US 10,047,130
Granted Patent B2
US 10,047,130 · App. 15/127,337 · Granted Aug 14, 2018

Methods and compositions for red-shifted chromophore substitution for optogenetic applications

Inventors: Joseph C. Corbo (St. Louis, MO); Jennifer Enright (St. Louis, MO); Matthew Toomey (St. Louis, MO)
Assignee: WASHINGTON UNIVERSITY
C07K14/405A61K48/00C12N9/0008C12N9/0071C12N15/86C12Y102/01036C07K2319/50C12N2750/14143
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Quick Facts
Patent No.
US 10,047,130
App. No.
15/127,337
Granted
Aug 14, 2018
Kind
B2
Abstract

The present disclosure provides compositions and methods used for optogenetics, wherein the composition comprises an optogenetic device and a retinoid processing enzyme.

Claims (6)

1. A composition comprising a vector, the vector comprising a polynucleotide sequence encoding a polypeptide, the polypeptide comprising at least one optogenetic device and a retinoid processing enzyme.

2. The composition of claim 1 , wherein the polypeptide comprises a proteolytic cleavage site between the optogenetic device and the retinoid processing enzyme.

3. The composition of claim 1 , wherein the optogenetic device comprises an optogenetic activator.

4. The composition of claim 3 , wherein the optogenetic activator is ReaChR.

5. The composition of claim 1 , wherein the retinoid processing enzyme is a retinal 3,4-dehydrogenase.

6. The composition of claim 5 , wherein the retinoid processing enzyme is Cyp27c1.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2018
From: CORBO, JOSEPH C.; ENRIGHT, JENNIFER M.; TOOMEY, MATTHEW
To: WASHINGTON UNIVERSITY
Reel/Frame 044729/0608 →
CONFIRMATORY LICENSE Recorded Mar 3, 2017
From: WASHINGTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041888/0128 →
Continuity (3)
Provisional Application 61955074 · Mar 18, 2014
Provisional Application 62014289 · Jun 19, 2014
Related Publication 20170183385A1 · Jun 29, 2017