Antimicrobial hydrochloric acid catheter lock solution and method of use
A catheter lock solution includes a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar. This hydrochloric acid solution may be used to lock a catheter and/or salvage an infected catheter.
1. A method of inhibiting microbial contamination in a catheter, the method comprising the step of:
infusing a lumen of the catheter with a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar, wherein the hydrochloric acid solution further includes silver sulfadiazine.
2. The method according to claim 1 , further comprising the step of:
allowing the hydrochloric acid solution to dwell within the lumen for about an hour.
3. The method according to claim 2 , further comprising the step of:
drawing the hydrochloric acid solution from the lumen following the hour dwell time.
4. The method according to claim 3 , further comprising the step of:
flushing the catheter with a saline solution following the withdrawal of the hydrochloric acid solution.
5. The method according to claim 1 , wherein the hydrochloric acid solution has a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
6. The method according to claim 1 , wherein the hydrochloric acid solution further includes an antimicrobial agent.
7. The method according to claim 1 , wherein the silver sulfadiazine is at a concentration of at least 128 ppm.
8. The method according to claim 6 , wherein the antimicrobial agent includes Rifampin and Minocycline.
9. The method according to claim 1 , wherein the hydrochloric acid solution further includes an anti-coagulant.
10. The method according to claim 9 , wherein the anti-coagulant is heparin.
11. A method of treating a patient having a microbial contamination of an indwelling catheter, the method comprising the steps of:
infusing a lumen of the catheter with a hydrochloric acid solution having a concentration of 0.3 Molar to 1.0 Molar, wherein the hydrochloric acid solution further includes silver sulfadiazine.
12. The method according to claim 11 , further comprising the step of:
allowing the hydrochloric acid solution to dwell within the lumen for about 30 minutes.
13. The method according to claim 12 , further comprising the step of:
drawing the hydrochloric acid solution from the lumen following the hour dwell time.
14. The method according to claim 13 , further comprising the step of:
flushing the catheter with a saline solution following the withdrawal of the hydrochloric acid solution.
15. The method according to claim 11 , wherein the hydrochloric acid solution has a hydrochloric acid concentration of 0.3 Molar to 0.5 Molar.
16. The method according to claim 11 , further comprising the step of:
selecting a hydrochloric acid concentration of 0.4 Molar to 1.0 Molar in response to a biofilm of microbial contamination being present in the catheter.
17. The method according to claim 11 , wherein the hydrochloric acid solution further includes an antimicrobial agent.
18. The method according to claim 11 , wherein the silver sulfadiazine is at a concentration of at least 128 ppm.
19. The method according to claim 17 , wherein the antimicrobial agent includes Rifampin and Minocycline.
20. The method according to claim 11 , wherein the hydrochloric acid solution further includes an anti-coagulant.
21. The method according to claim 20 , wherein the anti-coagulant is heparin.