Pneumatically coupled direct drive fluid control system and process

1. A process for controlling an infusion of fluid from a fluid source to a liquid sink, comprising:

a) exerting a negative pressure on a gas reservoir in fluid communication with a gas-side chamber separated from a fluid-side chamber by a flexible membrane to draw fluid from the fluid source into the fluid-side chamber through a one-way inlet valve until the fluid-side chamber fills with fluid;

b) exerting a positive pressure on the gas reservoir in fluid communication with the gas-side chamber by effecting a plurality of known, incremental changes in a volume of the gas reservoir as a series of discrete steps to deliver fluid in the fluid-side chamber to the liquid sink through a one-way outlet valve, wherein the one-way inlet valve and one way outlet valve each are passively operated and only open when a pressure differential between an upstream fluid and a downstream fluid reaches a predetermined cracking pressure;

c) monitoring pressure in the gas reservoir during the steps of exerting the negative pressure and exerting the positive pressure; and

d) determining volumes of fluid in the fluid-side chamber from the plurality of known, incremental changes in the volume of the gas reservoir and the gas-side chamber and any connecting dead space by an ideal gas law relationship, wherein P 1 V 1 =P 2 V 2 , wherein P 1 and P 2 are pressures measured before and after volume changes, respectively, and V 1 and V 2 are volumes before and after the volume changes, respectively.

2. The process of claim 1 , further comprising repeating steps a through d, and wherein a total volume of fluid delivered to the liquid sink is determined after each successive repetition of steps a through d by adding a calculated volume change to a previously determined total volume.

3. The process of claim 1 , wherein in step a, the negative pressure is exerted until the pressure differential across the one-way inlet valve reaches the predetermined cracking pressure of the one-way inlet valve such that the one way inlet valve opens and fluid flows into the fluid-side chamber, and the negative pressure is exerted additionally to continue drawing fluid into the fluid-side chamber until the fluid-side chamber fills with fluid as determined by a volume determined in step d.

4. The process of claim 1 , wherein in step b, the positive pressure is exerted until the pressure differential across the one-way outlet valve reaches the predetermined cracking pressure of the one-way outlet valve such that the one-way outlet valve opens and fluid flows out of the fluid-side chamber, and the positive pressure is exerted additionally to continue delivering fluid out of the fluid-side chamber until the fluid-side chamber is emptied of fluid as determined by a volume determined in step d.

5. The process of claim 1 , wherein a volume of the fluid-side chamber and the gas-side chamber together is fixed and the volume of the gas reservoir is variable by a known and controlled amount using a reciprocating element and a bidirectional linear actuator.

6. The process of claim 1 , wherein a pressure trend is determined from the step of monitoring the pressure, and further wherein the pressure trend is indicative of one or more conditions upstream of the fluid-side chamber, downstream of the fluid-side chamber, or both, the one or more conditions selected from the group consisting of one or more of: an indication of remaining fluid in the fluid source, air in the fluid-side chamber, an occlusion in an upstream line, an occlusion in a downstream line, and a disconnection in an output line.

7. The process of claim 1 , wherein a pressure trend is determined from the step of monitoring the pressure, and further wherein the pressure trend is indicative of air in a fluid flow path.

8. The process of claim 1 , wherein the negative pressure and positive pressure are exerted using a reciprocating element selected from the group consisting of:

a bellows end coupled at one end to a linear actuator, an interior of the bellows comprising at least part of the gas reservoir; and

a piston reciprocable within a cylinder, the cylinder comprising at least part of the gas reservoir.

9. The process of claim 1 , wherein in step d, sensed pressure data is received before and after each known, incremental change in volume of the gas reservoir, the sensed pressure data is compared to a known change in gas volume resulting from said known, incremental change in volume of the gas reservoir, and a total volume of gas is calculated based on the sensed pressure data and the known, incremental change in volume of the gas reservoir based on said ideal gas law relationship between the sensed pressure data and the known, incremental change in volume of the gas reservoir.

10. The process of claim 1 , further comprising:

periodically determining a total volume of fluid delivered to the liquid sink; and

repeating steps a through d and until the total volume of fluid delivered to the liquid sink is equal to a predetermined target volume.

11. The process of claim 1 , further comprising:

periodically monitoring changes in a volume of fluid delivered to the liquid sink over time to calculate a flow rate of fluid delivered to the liquid sink; and

adjusting a rate of effecting the plurality of known, incremental changes in volume of the gas reservoir until the flow rate of fluid delivered to the liquid sink is equal to a predetermined target flow rate.