Probiotic compositions for use in the treatment of bowel diseases
The present disclosure is directed to methods of administering and compositions comprising Lactobacillus plantarum CECT 7478, Lactobacillus plantarum CECT 7485, and Pediococcus acidilactici CECT 7483 or a mutant or variant thereof. The compositions and methods are useful in the probiotic treatment of bowel diseases or conditions such as Inflammatory Bowel Disease, Irritable Bowel Syndrome, and abdominal distension and bloating.
1. A method of treating abdominal distension and bloating, comprising administering to a patient in need thereof a therapeutically effective amount of an ingestible probiotic composition comprising at least one strain selected from the group consisting of:
(a) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7484, per gram weight of the composition;
(b) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7485, per gram weight of the composition; and
(c) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Pediococcus acidilactici deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7483, per gram weight of the composition.
2. The method of claim 1 , wherein the isolated strain has been cultivated in a suitable culture medium and post-treated after cultivation to obtain a biologically pure culture, and wherein the resulting biologically pure culture is in the form of a liquid or solid.
3. The method of claim 2 , wherein the post-treatment is freeze drying.
4. The method of claim 1 , wherein the composition further comprises at least one pharmaceutically acceptable excipient.
5. The method of claim 1 , wherein the composition further comprises at least one veterinary acceptable excipient.
6. The method of claim 1 , wherein the composition further comprises at least one edible ingredient.
7. The method of claim 6 , wherein the composition is a dietary supplement.
8. A method of treating inflammatory bowel conditions or disorders comprising administering to a patient in need thereof a therapeutically effective amount of an ingestible probiotic composition comprising at least one strain selected from the group consisting of:
(a) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7484, per gram weight of the composition;
(b) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7485, per gram weight of the composition; and
(c) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Pediococcus acidilactici deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7483, per gram weight of the composition.
9. The method of claim 8 , wherein the bowel condition or disorder is bowel inflammation.
10. The method of claim 8 , wherein the bowel condition or disorder is Inflammatory Bowel Disease.
11. The method of claim 8 , wherein the isolated strain has been cultivated in a suitable culture medium and post-treated after cultivation to obtain a biologically pure culture, and wherein the resulting biologically pure culture is in the form of a liquid or solid.
12. The method of claim 11 , wherein the post-treatment is freeze drying.
13. The method of claim 8 , wherein the composition further comprises at least one pharmaceutically acceptable excipient.
14. The method of claim 8 , wherein the composition further comprises at least one veterinary acceptable excipient.
15. The method of claim 8 , wherein the composition further comprises at least one edible ingredient.
16. The method of claim 15 , wherein the composition is a dietary supplement.
17. A method of treating Irritable Bowel Syndrome or disorders with similar symptoms comprising administering to a patient in need thereof a therapeutically effective amount of an ingestible probiotic composition comprising at least one strain selected from the group consisting of:
(a) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7484, per gram weight of the composition;
(b) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Lactobacillus plantarum deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7485, per gram weight of the composition; and
(c) from about 10 5 cfu to about 10 12 cfu of the isolated strain of Pediococcus acidilactici deposited in the Spanish Type Culture Collection (CECT) under the accession number CECT 7483, per gram weight of the composition.
18. The method of claim 17 , wherein the isolated strain has been cultivated in a suitable culture medium and post-treated after cultivation to obtain a biologically pure culture, and wherein the resulting biologically pure culture is in the form of a liquid or solid.
19. The method of claim 18 , wherein the post-treatment is freeze drying.
20. The method of claim 17 , wherein the composition further comprises at least one pharmaceutically acceptable excipient.
21. The method of claim 17 , wherein the composition further comprises at least one veterinary acceptable excipient.
22. The method of claim 17 , wherein the composition further comprises at least one edible ingredient.
23. The method of claim 22 , wherein the composition is a dietary supplement.