IP Library › Granted Patent US 10,792,348
Granted Patent B2
US 10,792,348 · App. 15/135,832 · Granted Oct 6, 2020

Enhancing T cell activation using altered MHC-peptide ligands

Inventor: Larry R. Pease (Rochester, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61K39/0011A61K35/17A61K39/0008C07K14/70539C12N7/00G01N33/505G01N33/56977A61K38/00A61K2039/5158A61K2039/53A61K2039/572C12N2710/10043G01N2333/70539
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Quick Facts
Patent No.
US 10,792,348
App. No.
15/135,832
Granted
Oct 6, 2020
Kind
B2
Abstract

Materials and methods for identifying and using MEW molecule variants for activating self-reactive T cells in a peptide-specific manner, and their use to focus autoimmune cellular responses against diseases such as cancers and persisting viral infections, are described.

Claims (2)

1. A method comprising contacting a cell in a human with a virus particle comprising a nucleic acid sequence that encodes a variant of a wild-type human HLA-A0201 molecule consisting of a non-conservative amino acid substitution of G 162 to tryptophan, tyrosine, or phenylalanine.

2. The method of claim 1 , wherein the virus is an adenovirus.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 18, 2017
From: PEASE, LARRY R.
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 042427/0413 →
CONFIRMATORY LICENSE Recorded Jun 30, 2016
From: MAYO CLINIC ROCHESTER
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 039217/0637 →
Continuity (3)
Continuation 13299754 · Nov 18, 2011
Provisional Application 61415227 · Nov 18, 2010
Related Publication 20160361402A1 · Dec 15, 2016