Combination of immunotherapy with local chemotherapy for the treatment of malignancies
The presently disclosed subject matter provides methods, compositions, and kits for the treatment of cancer using a combination treatment comprising a locally administered chemotherapy and an immunotherapeutic agent. The presently disclosed subject matter also provides methods of promoting the combination treatment and instructing a patient to receive the combination treatment are also provided, as well immunotherapeutic, non-immunosuppressive compositions comprising the combination treatment, and methods of using the immunotherapeutic, non-immunosuppressive compositions for treating cancer.
1. A method for reducing recurrence of recurrent human glioblastoma multiforme, the method consisting of:
administering to a human patient with recurrent glioblastoma multiforme an effective amount of a combination treatment consisting of:
(a) a locally administered chemotherapy comprising a BCNU implantable wafer; and
(b) nivolumab,
wherein recurrence of the glioblastoma multiforme is inhibited.
2. A method for treating human glioblastoma and reducing glioblastoma recurrence in humans, the method consisting of:
(i) surgically removing all or a portion of a solid glioblastoma tumor in a human patient with recurrent glioblastoma multiforme; and
(ii) administering to the human patient with recurrent glioblastoma multiforme an effective amount of a combination treatment consisting of:
(a) a locally administered chemotherapy comprising a BCNU implantable wafer; and
(b) nivolumab,
wherein recurrence of the glioblastoma is inhibited.
3. The method of claim 2 , wherein locally administered chemotherapy is administered intratumorally and/or within a tumor bed.
4. The method of claim 2 , wherein CD8+IFNγ producing cells are increased in the human patient with recurrent glioblastoma multiforme.
5. The method of claim 2 , wherein the locally administered chemotherapy increases antigen release from tumor cells in the human patient with recurrent glioblastoma multiforme.
6. A method for increasing antigen release from tumor cells in a human patient with glioblastoma, the method consisting of:
administering to the human patient with glioblastoma an effective amount of a combination treatment consisting of:
(a) a locally administered chemotherapy comprising a BCNU implantable wafer; and
(b) nivolumab.
7. The method of claim 6 , wherein the glioblastoma is recurrent glioblastoma multiforme.
8. A method for increasing CD8+IFNγ producing cells in a human patient with glioblastoma, the method consisting of:
administering to the human patient with glioblastoma an effective amount of a combination treatment consisting of:
(a) a locally administered chemotherapy comprising a BCNU implantable wafer; and
(b) nivolumab.
9. The method of claim 8 , wherein the glioblastoma is recurrent glioblastoma multiforme.