System and method to identify sources associated with biological rhythm disorders
In a system and method for identifying a driver of a source associated with a heart rhythm disorder, data are accessed from a plurality of sensors representing biological activity in the heart. A first region and a second region of the heart, which comprise the source of the heart rhythm disorder, are identified. If the first region of the heart has repeating centrifugal activation and controls the second region of the heart for at least a predetermined number of beats, the first region is identified as controlling the source of the heart rhythm disorder.
1. A method of identifying a region associated with controlling a source of a heart rhythm disorder, the method comprising:
accessing, by a computing device, data from a plurality of sensors representing biological activity in the heart;
identifying, by the computing device, a first and a second region of the heart comprising the source of the heart rhythm disorder, wherein the first region of the heart has repeating centrifugal activation; and
determining, by the computing device, whether the first region controls the second region of the heart for at least a predetermined number of beats; and
identifying the first region as controlling the source when the first region controls the second region for at least a predetermined number of beats.
2. The method of claim 1 , wherein a sequence of centrifugal activation within the first region directly controls the second region.
3. The method of claim 1 , wherein a sequence of centrifugal activation within the first region directly controls the second region in a centrifugal pattern.
4. The method of claim 1 , wherein a sequence of centrifugal activation is spatially located within the first region between the beats.
5. The method of claim 1 , wherein a sequence of centrifugal activation spatially moves within the first region between the beats.
6. The method of claim 1 , wherein the first region has an area of less than 5 cm 2 .
7. The method of claim 1 , further comprising determining stability of the repeating activation by computing indexes of centrifugal activation within the first region.
8. The method of claim 7 , wherein the indexes of centrifugal activation is one or more of vectors of activation, linear velocity, correlation analysis or and spatial maps showing progressive spatial activation.
9. The method of claim 7 , wherein the indexes of centrifugal activation are displayed on a map of sensor locations indicating higher and lower indexes of centrifugal activation.
10. The method of claim 1 , further comprising classifying the first region as a driver if the first region controls the second region for a plurality of the beats.
11. The method of claim 1 , wherein the first region is a driver of the source.
12. The method of claim 11 , wherein the driver is an internal driver of the source.
13. The method of claim 1 , wherein the first region controls the source.
14. The method of claim 1 , wherein the source is a focal source.
15. The method of claim 14 , wherein the first region is a core of the focal source.
16. The method of claim 11 , wherein the source comprises a focal source and the driver is a core of the focal source.
17. A system of identifying a region associated with controlling a source of a heart rhythm disorder, the system comprising:
a processor; and
a storage medium storing instructions that, when executed by the processor, cause the processor to perform operations comprising:
accessing data from a plurality of sensors representing biological activity in the heart;
identifying a first and a second region of the heart comprising the source of the heart rhythm disorder, wherein the first region has repeating centrifugal activation;
determining whether the first region controls the second region of the heart for at least a predetermined number of beats; and
identifying the first region as controlling the source when the first region controls the second region for at least the predetermined number of beats.
18. The system of claim 17 , wherein a sequence of centrifugal activation within the first region directly controls the second region.
19. The system of claim 17 , wherein a sequence of centrifugal activation within the first region directly controls the second region in a centrifugal pattern.
20. The system of claim 17 , wherein a sequence of activation is spatially located within the first region between the beats.
21. The system of claim 17 , wherein a sequence of activation moves spatially within the first region between the beats.
22. The system of claim 17 , wherein the first region has an area of less than 5 cm 2 .
23. The system of claim 17 , further comprising determining stability of the repeating activation by computing indexes of centrifugal activation within the first region.
24. The system of claim 23 , wherein the indexes of centrifugal activation includes one or more of vectors of activation, linear velocity, correlation analysis and spatial maps showing progressive spatial activation.
25. The system of claim 24 , wherein the indexes of centrifugal activation are displayed on a map of sensor locations indicating higher and lower indexes of centrifugal activation.
26. The system of claim 17 , further comprising classifying the first region as a driver if the first region controls the second region for a plurality of the beats.
27. The system of claim 17 , wherein the first region is a driver of the source.
28. The system of claim 27 , wherein the driver is an internal driver of the source.
29. The system of claim 27 , wherein the source comprises a focal source and the driver is a core of the focal source.
30. The system of claim 17 , wherein the first region controls the source.
31. The system of claim 17 , wherein the source is a focal source.
32. The system of claim 31 , wherein the first region is a core of the focal source.