Compositions for treating CMT and related disorders

1. A pharmaceutical composition comprising:

(i) baclofen or a salt thereof,

(ii) sorbitol or a salt thereof, and

(iii) naltrexone or a salt thereof;

in a relative weight ratio of the baclofen, sorbitol, and naltrexone of 8.6:300:1;

and a pharmaceutically suitable excipient or carrier.

2. The composition according to claim 1 , wherein the sorbitol is D-sorbitol.

3. The composition according to claim 1 , wherein said composition is formulated for an oral administration.

4. A method for treating Charcot Marie Tooth disease (CMT) in a human subject in need thereof, said method comprising the step of administering to said human subject the composition according to claim 1 .

5. The method according to claim 4 , wherein the CMT is CMT1A.