Use of an oleogel containing triterpene for healing wounds
An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.
1. A method for treating epidermolysis bullosa in a patient in need thereof, comprising topically administering to the patient an oleogel comprising a triterpene fraction, wherein the triterpene fraction comprises betulin.
2. The method of claim 1 , wherein the method comprises topically administering the oleogel to an area of wounds caused by epidermolysis bullosa.
3. The method of claim 1 , wherein the method comprises topically administering the oleogel to an area of epidermolysis bullosa comprising blisters.
4. The method of claim 1 , wherein the triterpene fraction comprises between 1 weight-percent and 20 weight-percent of the oleogel.
5. The method of claim 4 , wherein the triterpene fraction comprises between 6 weight-percent and 12 weight-percent of the oleogel.
6. The method of claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 60 weight-percent.
7. The method of claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 80 weight-percent.
8. The method of claim 1 , wherein the triterpene fraction further comprises lupeol.
9. The method of claim 8 , wherein the joint fraction of betulin and lupeol in the triterpene is greater than 80 weight-percent in the triterpene fraction.
10. The method of claim 8 , wherein the joint fraction of betulin and lupeol is greater than 85 weight-percent in the triterpene fraction.
11. The method of claim 1 , wherein the oleogel further comprises a nonpolar liquid.
12. The method of claim 11 , wherein the nonpolar liquid is a plant, animal, mineral, or synthetic oil.
13. The method of claim 12 , wherein the plant oil is a vegetable oil which is selected from one of the following: sunflower oil, olive oil, avocado oil, and almond oil.
14. The method of claim 11 , wherein the nonpolar liquid consists of sunflower oil.
15. The method of claim 11 , wherein the nonpolar liquid fraction comprises between 80 weight-percent and 99 weight-percent in relation to the total weight of the oleogel, and wherein the triterprene fraction comprises between 1 weight-percent and 20 weight-percent in relation to the total weight of the oleogel.
16. The method of claim 1 , wherein the oleogel further comprises betulinic acid, oleanolic acid, and erythrodiol.
17. The method of claim 1 , wherein the patient is a human.
18. The method of claim 1 , wherein the epidermolysis bullosa is epidermolysis bullosa junctionalis, epidermolysis bullosa simplex, dystrophic epidermolysis bullosa, or epidermolysis bullosa dystrophica inversa.