IP Library Granted Patent US 9,827,214
Granted Patent B2
US 9,827,214 · App. 15/142,679 · Granted Nov 28, 2017

Use of an oleogel containing triterpene for healing wounds

Inventor: Armin Scheffler (Niefern-Öschelbronn, DE)
Assignee: AMRYT RESEARCH LIMITED
A61K31/19A61K9/0014A61K9/06A61K31/045A61K31/56A61K47/06A61K47/44
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 9,827,214
App. No.
15/142,679
Granted
Nov 28, 2017
Kind
B2
Abstract

An oleogel comprising a non-polar liquid and a powder containing triterpene is provided as an oleogel that may be used for healing wounds.

Claims (18)

1. A method for treating epidermolysis bullosa in a patient in need thereof, comprising topically administering to the patient an oleogel comprising a triterpene fraction, wherein the triterpene fraction comprises betulin.

2. The method of claim 1 , wherein the method comprises topically administering the oleogel to an area of wounds caused by epidermolysis bullosa.

3. The method of claim 1 , wherein the method comprises topically administering the oleogel to an area of epidermolysis bullosa comprising blisters.

4. The method of claim 1 , wherein the triterpene fraction comprises between 1 weight-percent and 20 weight-percent of the oleogel.

5. The method of claim 4 , wherein the triterpene fraction comprises between 6 weight-percent and 12 weight-percent of the oleogel.

6. The method of claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 60 weight-percent.

7. The method of claim 1 , wherein the fraction of betulin in the triterpene fraction is greater than 80 weight-percent.

8. The method of claim 1 , wherein the triterpene fraction further comprises lupeol.

9. The method of claim 8 , wherein the joint fraction of betulin and lupeol in the triterpene is greater than 80 weight-percent in the triterpene fraction.

10. The method of claim 8 , wherein the joint fraction of betulin and lupeol is greater than 85 weight-percent in the triterpene fraction.

11. The method of claim 1 , wherein the oleogel further comprises a nonpolar liquid.

12. The method of claim 11 , wherein the nonpolar liquid is a plant, animal, mineral, or synthetic oil.

13. The method of claim 12 , wherein the plant oil is a vegetable oil which is selected from one of the following: sunflower oil, olive oil, avocado oil, and almond oil.

14. The method of claim 11 , wherein the nonpolar liquid consists of sunflower oil.

15. The method of claim 11 , wherein the nonpolar liquid fraction comprises between 80 weight-percent and 99 weight-percent in relation to the total weight of the oleogel, and wherein the triterprene fraction comprises between 1 weight-percent and 20 weight-percent in relation to the total weight of the oleogel.

16. The method of claim 1 , wherein the oleogel further comprises betulinic acid, oleanolic acid, and erythrodiol.

17. The method of claim 1 , wherein the patient is a human.

18. The method of claim 1 , wherein the epidermolysis bullosa is epidermolysis bullosa junctionalis, epidermolysis bullosa simplex, dystrophic epidermolysis bullosa, or epidermolysis bullosa dystrophica inversa.

Assignments (7)
MERGER Recorded Jan 12, 2024
From: AMRYT RESEARCH LIMITED
To: AMRYT PHARMACEUTICALS DESIGNATED ACTIVITY COMPANY
Reel/Frame 066110/0568 →
RELEASE OF SECURITY INTEREST Recorded Apr 13, 2023
From: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
To: AMRYT GENETICS LIMITED; AMRYT PHARMACEUTICALS, INC.; AMRYT ENDO, INC.; AMRYT RESEARCH LIMITED
Reel/Frame 063318/0849 →
RELEASE OF SECURITY INTEREST Recorded Feb 23, 2022
From: CANTOR FITZGERALD SECURITIES, AS ADMINISTRATIVE AGENT
To: AEGERION PHARMACEUTICALS, INC.; AMRYT RESEARCH LIMITED
Reel/Frame 059074/0604 →
SECURITY INTEREST Recorded Feb 18, 2022
From: AMRYT RESEARCH LIMITED
To: ARES CAPITAL CORPORATION, AS ADMINISTRATIVE AGENT
Reel/Frame 059049/0328 →
SECURITY INTEREST Recorded Sep 24, 2019
From: AMRYT RESEARCH LIMITED
To: CANTOR FITZGERALD SECURITIES, AS ADMINISTRATIVE AGENT
Reel/Frame 050478/0347 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2017
From: SCHEFFLER, ARMIN, DR.
To: BIRKEN AG
Reel/Frame 042258/0994 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 5, 2017
From: BIRKEN AG
To: AMRYT RESEARCH LIMITED
Reel/Frame 042259/0006 →
Priority Claims (1)
DE 10 2009 047 092 · Nov 24, 2009 · national
Continuity (2)
Continuation 13509416
Related Publication 20160317481A1 · Nov 3, 2016