IP Library Granted Patent US 10,174,347
Granted Patent B2
US 10,174,347 · App. 15/142,877 · Granted Jan 8, 2019

Method for producing lactic acid from organic waste

Inventors: Gregory Stephanopoulos (Winchester, MA); Devin Hedley Currie (Somerville, MA); Kristen Jean Fortnam (Somerville, MA)
Assignee: Massachusetts Institute of Technology
C12P7/56C12P39/00
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Quick Facts
Patent No.
US 10,174,347
App. No.
15/142,877
Granted
Jan 8, 2019
Kind
B2
Abstract

Aspects of the invention relate to methods for producing lactic acid from organic waste, comprising contacting organic waste with a microbial community to form a fermentation mixture, and fermenting the fermentation mixture under controlled pH and temperature conditions for a time sufficient to produce lactic acid.

Claims (41)

1. A method for producing lactic acid from organic waste, comprising

contacting organic waste with a controlled microbial community to form a fermentation mixture,

controlling the pH and temperature conditions of the controlled microbial community in the fermentation mixture, and

fermenting the fermentation mixture under the controlled pH and temperature conditions for a time sufficient to produce lactic acid,

wherein the controlled microbial community comprises Firmicutes, Bacteroides and Spirochetes,

wherein the fermentation mixture has a solid content,

wherein the pH is controlled to between 3.0 and 6.0,

wherein the temperature is controlled to between 20° C. and 50° C., and

wherein the method does not comprise sterilization of the organic waste.

2. The method of claim 1 , wherein the method does not comprise enzyme addition to the fermentation mixture.

3. The method of claim 1 , wherein the organic waste is food waste or agricultural waste.

4. The method of claim 1 , wherein prior to fermentation, the organic waste is mechanically disrupted to a particle size of approximately 1 mm or smaller.

5. The method of claim 4 , wherein the mechanical disruption comprises shredding or grinding.

6. The method of claim 1 , wherein the pH is adjusted by addition of sodium hydroxide or other bases.

7. The method of claim 1 , wherein the temperature of the fermentation mixture is about 37° C.

8. The method of claim 1 , further comprising shifting the pH to between pH 3.86 and pH 4.75, inclusive, at or near the end of fermentation.

9. The method of claim 1 , wherein 60-100 grams of lactic acid per liter is produced.

10. The method of claim 1 , wherein the pH is adjusted to between pH 5.0 to pH 6.0.

11. The method of claim 10 , wherein the pH is adjusted to about pH 5.5.

12. The method of claim 1 , wherein the pH is controlled to be at or below 6.0 and above the pKa of lactic acid.

13. A method for producing lactic acid from organic waste, comprising

contacting organic waste with a controlled microbial community to form a fermentation mixture,

controlling the pH and temperature conditions of the controlled microbial community in the fermentation mixture, and

fermenting the fermentation mixture under the controlled pH and temperature conditions for a time sufficient to produce lactic acid,

wherein the controlled microbial community comprises Firmicutes, Bacteroides and Spirochetes,

wherein the fermentation mixture has a solid content,

wherein the temperature is controlled to between 20° C. and 50° C., and

wherein the pH is controlled to be at or below 6.0 and above the pKa of lactic acid.

14. The method of claim 13 , wherein at least 60 or more grams of lactic acid per liter are produced.

15. The method of claim 13 , wherein 60-100 grams of lactic acid per liter or 60-150 grams of lactic acid per kilogram of organic waste is produced.

16. A method for producing lactic acid from organic waste, comprising

contacting organic waste with a controlled microbial community to form a fermentation mixture,

controlling the pH and temperature conditions of the controlled microbial community in the fermentation mixture, and

fermenting the fermentation mixture under the controlled pH and temperature conditions for a time sufficient to produce lactic acid,

wherein the controlled microbial community comprises Firmicutes, Bacteroides and Spirochetes,

wherein the fermentation mixture has a solid content,

wherein the pH is controlled to between 3.0 and 6.0,

wherein the temperature is controlled to between 20° C. and 50° C., and

wherein 60 or more grams of lactic acid per liter are produced.

17. The method of claim 16 , wherein 60-100 grams of lactic acid per liter or 60-150 grams of lactic acid per kilogram of organic waste is produced.

18. The method of claim 17 , wherein the organic waste is food waste.

Assignments (3)
CONFIRMATORY LICENSE Recorded Nov 20, 2023
From: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 065631/0175 →
CONFIRMATORY LICENSE Recorded May 19, 2020
From: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 052698/0435 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 9, 2017
From: STEPHANOPOLOUS, GREGORY; CURRIE, DEVIN HEDLEY; FORTNAM, KRISTEN JEAN
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 043247/0043 →
Continuity (2)
Provisional Application 62154802 · Apr 30, 2015
Related Publication 20160355849A1 · Dec 8, 2016