IP Library › Granted Patent US 10,292,986
Granted Patent B2
US 10,292,986 · App. 15/144,286 · Granted May 21, 2019

Methods for treating epithelian mesenchymal transition related diseases

Inventors: Bing Tian (Galveston, TX); Allan Brasier (Galveston, TX)
Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
A61K31/551A61K45/06
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,292,986
App. No.
15/144,286
Granted
May 21, 2019
Kind
B2
Abstract

Certain embodiments are directed to methods of treating chronic lung diseases in a subject comprising administering to a subject diagnosed with, exhibiting symptoms of, or at risk of developing a chronic lung disease a therapeutically effective amount of a BRD4 inhibitor or a CDK9 inhibitor to the subject.

Claims (4)

1. A method of treating epithelial-mesenchymal transition (EMT) lung fibrosis in a subject comprising administering a therapeutically effective amount of a small molecule BRD4 inhibitor to a subject having or at risk of developing EMT lung fibrosis.

2. The method of claim 1 , wherein the BRD4 inhibitor is administered by inhalation or instillation.

3. The method of claim 1 , wherein the BRD4 inhibitor is administered at a dose of 150 to 500 mg/day.

4. The method of claim 1 , wherein the BRD4 inhibitor is JQ1.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jan 3, 2017
From: UNIVERSITY OF TEXAS MEDICAL BR GALVESTON
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 041231/0129 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2016
From: TIAN, BING; BRASIER, ALLAN
To: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
Reel/Frame 038452/0504 →
Continuity (2)
Provisional Application 62155950 · May 1, 2015
Related Publication 20160317548A1 · Nov 3, 2016
Cited By (1)
US 12,384,777