Compositions and methods for treating conditions of compromised skin barrier function
Compositions and methods useful in treating dermatological disorders are described. The methods include applying to the skin a composition comprising a reactive reinforcing component and a cross-linking component, wherein the cross-linking component facilitates a reaction to form a film in situ on the skin.
1. A method for treating a dermatological disorder in a subject in need thereof, comprising:
applying to the skin of the subject a composition comprising
a) a reactive reinforcing component comprising
1) a reactive constituent comprising at least one alkenyl functionalized organopolysiloxane and at least one hydride functionalized polysiloxane; and
2) a reinforcing constituent; and
b) a cross-linking component comprising at least one catalyst;
wherein the cross-linking component facilitates a reaction to form a film in situ on the skin,
wherein the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component comprises vinyl groups, and
wherein the reactive reinforcing component has a molar ratio of vinyl to hydride functional groups of between about 1:10 and about 1:100.
2. The method of claim 1 , wherein the dermatological disorder is lichen simplex chronicus, cutaneous lupus, psoriasis, eczema, chronic dry skin, xeroderma, rosacea, ichthyosis, an ulcer, or any combination thereof.
3. The method of claim 1 , wherein the dermatological disorder is a condition of compromised skin barrier function.
4. The method of claim 1 , wherein the composition is used in combination with one or more additional therapeutic agents.
5. The method of claim 4 , wherein the one or more additional therapeutic agent is a moisturizer, mineral oil, petroleum jelly, coal tar, anthralin, corticosteroids, fluocinonide, vitamin D3 analoges, retinoids, methotrexate, cyclosporine, a monoclonal antibody, pimecrolimus, tacrolimus, azathioprine, fluoruracil, salicylic acid, benzoyl peroxide, antibiotics, alpha-hydroxy acids, or a combination thereof.
6. The method of claim 2 , wherein the dermatological disorder is eczema.
7. The method of claim 1 , wherein said reactive reinforcing component and said cross-linking component are prevented from coming into contact prior to use.
8. The method of claim 1 , wherein said reactive reinforcing component has a viscosity of between about 5,000 and about 1,000,000 cSt or cP at 25° C.
9. The method of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component has a viscosity of at least about 100,000 cSt or cP at 25° C.
10. The method of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is selected from the group consisting of vinyl terminated polydimethylsiloxane; vinyl terminated diphenylsiloxane-dimethylsiloxane copolymers; vinyl terminated polyphenylmethylsiloxane, vinylphenylmethyl terminated vinylphenylsiloxane-phenylmethylsiloxane copolymer; vinyl terminated trifluoropropylmethylsiloxane-dimethylsiloxane copolymer; vinyl terminated diethylsiloxane-dimethylsiloxane copolymer; vinylmethylsiloxane-dimethylsiloxane copolymer, trimethylsiloxy terminated; vinylmethylsiloxane-dimethylsiloxane copolymers, silanol terminated; vinylmethylsiloxane-dimethylsiloxane copolymers, vinyl terminated; vinyl gums; vinylmethylsiloxane homopolymers; vinyl T-structure polymers; monovinyl terminated polydimethylsiloxanes; vinylmethylsiloxane terpolymers; vinylmethoxysilane homopolymers and combinations thereof.
11. The method of claim 1 , wherein at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is vinyl terminated polydimethylsiloxane.
12. The method of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component has a weight percent of vinyl of between about 0.01 and about 0.1.
13. The method of claim 11 , wherein the vinyl terminated polydimethylsiloxane of the reactive reinforcing component is of formula IIa:
wherein:
R 1a, , R 3a′ , R 4a′ , R 5a′ , R 6a′ , R 8a′ , R 9a′ and R 10a′ are each independently selected from the group consisting of hydrogen, C 1-20 alkyl, C 2-20 alkenyl, C 5-10 aryl, hydroxyl and C 1-20 alkoxyl; and
p and q are each independently an integer from between 10 and about 6000.
14. The method of claim 1 , wherein the at least one hydride functionalized polysiloxane has a viscosity of at least about 5 cSt or cP at 25° C.
15. The method of claim 1 , wherein the at least one hydride functionalized polysiloxane is selected from the group consisting of hydride terminated polydimethylsiloxane; polyphenyl-(dimethylhydrosiloxy)siloxane, hydride terminated; methylhydrosiloxane-phenylmethylsiloxane copolymer, hydride terminated; methylhydrosiloxane-dimethylsiloxane copolymers, trimethylsiloxy terminated; polymethylhydrosiloxanes, trimethylsiloxy terminated; polyethylhydrosiloxane, triethylsiloxane, methylhydrosiloxane-phenyloctylmethylsiloxane copolymer; methylhydrosiloxane-phenyloctylmethylsiloxane terpolymer and combinations thereof.
16. The method of claim 1 , wherein the at least one hydride functionalized polysiloxane has a percent SiH content of between about 3 and about 45%.
17. The method of claim 1 , wherein the at least one hydride functionalized polysiloxane has a SiH content of between about 0.5 and about 10 mmol/g.
18. The method of claim 1 , wherein the at least one hydride functionalized polysiloxane is methylhydrosiloxane-dimethylsiloxane copolymers, trimethylsiloxy terminated.
19. The method of claim 1 , wherein the cross-linking component further comprises at least one alkenyl functionalized organopolysiloxane.
20. The method of claim 19 , wherein the at least one alkenyl functionalized organopolysiloxane of the cross-linking component comprises at least two vinyl groups.
21. The method of claim 1 , wherein the reactive reinforcing component has a molar ratio of vinyl to hydride functional groups of between about 1:25 and about 1:70.
22. The method of claim 1 , wherein the reactive reinforcing component has a molar ratio of vinyl to hydride functional groups of between about 1:30 and about 1:60.
23. The method according to claim 1 , wherein the composition is used in combination with phototherapy.
24. The method of claim 1 , wherein the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is of formula II:
wherein:
R 1a , R 2a , R 3a , R 4a , R 5a , R 6a , R 7a , R 8a , R 9a and R 10a are each independently selected from the group consisting of hydrogen, C 1-20 alkyl, C 2-20 alkenyl, C 5-10 aryl, hydroxyl and C 1-20 alkoxyl; and
p and q are each independently an integer from between 10 and about 6000.
25. The method of claim 21 , wherein:
the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is vinyl terminated polydimethylsiloxane; and
the at least one hydride functionalized polysiloxane is methylhydrosiloxane-dimethylsiloxane copolymers, trimethylsiloxy terminated.
26. The method of claim 25 , wherein the cross-linking component further comprises at least one alkenyl functionalized organopolysiloxane.
27. The method of claim 21 , wherein:
the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is a polymer of formula IIa:
and wherein:
R 1a′ , R 3a′ , R 4a′ , R 5a′ , R 6a′ , R 8a′ , R 9a′ , and R 10a′ are each independently C 1-20 alkyl; and
p and q are each independently an integer from between 10 and 6000.
28. The method of claim 21 , wherein:
the reactive reinforcing component comprises a vinyl terminated organopolysiloxane having a viscosity between about 150,000 and about 185,000 cSt or cP at 25° C., and an alkyl terminated hydride functionalized polysiloxane having a viscosity of between about 30 and about 100 cSt or cP at 25° C.; and
the cross-linking component comprises a platinum catalyst.
29. The method of claim 22 , wherein:
the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is vinyl terminated polydimethylsiloxane; and
the at least one hydride functionalized polysiloxane is methylhydrosiloxane-dimethylsiloxane copolymers, trimethylsiloxy terminated.
30. The method of claim 29 , wherein the cross-linking component further comprises at least one alkenyl functionalized organopolysiloxane.
31. The method of claim 22 , wherein:
the at least one alkenyl functionalized organopolysiloxane of the reactive reinforcing component is a polymer of formula IIa:
and wherein:
R 1a′ , R 3a′ , R 4a′ , R 5a′ , R 6a′ , R 8a′ , R 9a′ , and R 10a′ are each independently C 1-20 alkyl; and
p and q are each independently an integer from between 10 and 6000.
32. The method of claim 22 , wherein:
the reactive reinforcing component comprises a vinyl terminated organopolysiloxane having a viscosity between about 150,000 and about 185,000 cSt or cP at 25° C., and an alkyl terminated hydride functionalized polysiloxane having a viscosity of between about 30 and about 100 cSt or cP at 25° C.; and
the cross-linking component comprises a platinum catalyst.