Granted Patent B2

US 12,419,906 · App. 17/144,379 · Granted Sep 23, 2025

Inventors: Ariya Akthakul (Boston, MA); Nithin Ramadurai (Wakefield, MA); Amir Nashat (Boston, MA); Daniela Beccati (Watertown, MA); Melaney Bouthillette (Newton, MA)

Assignee: Shiseido Company, Limited

A61K31/80A61K9/0014A61K9/7015A61K31/573A61K31/58A61L26/0019A61L26/0061

Abstract

Claims (24)

1. A composition for in-situ formation of a layer over the skin of a subject, wherein said composition is a two-part composition comprising a first and a second part;

wherein said first part has a viscosity above 100 cP at about 25° C. and comprises as ingredients:

Polymer A, which is vinyl terminated polydimethylsiloxane having an average molecular weight above about 72,000 Da and below about 200,000 Da;

Polymer B, which is hydride terminated polydimethylsiloxane having an average molecular weight between about 2,200 and about 6,000 Da;

wherein said first part comprises about 50 to about 90% by weight of Polymer A, about 5 to about 30% by weight of Polymer B, and about 5 to about 15% by weight of a reinforcing component;

wherein said second part has a viscosity above about 100 cP at about 25° C. and comprises a catalyst that facilitates crosslinking of the Polymer A and Polymer B;

wherein said second part further comprises Polymer C, which is vinyl terminated polydimethylsiloxane having an average molecular weight below 17,500 Da; and

wherein said reinforcing component has particle size of from about 2 nm to about 1000 nm.

2. The composition of claim 1 , wherein said reinforcing component is selected from surface treated carbon, silver, mica, zinc sulfide, zinc oxide, titanium dioxide, aluminum oxide, clay, chalk, talc, calcite, barium sulfate, zirconium dioxide, polymer beads, silica, graphene, or combinations thereof.

3. The composition of claim 1 , wherein said reinforcing component is silica and/or surface-treated silica.

4. The composition of claim 3 , wherein the silica is fumed silica.

5. The composition of claim 3 , wherein the surface-treated silica is silica surface-treated with hexamethyldisilazane, polydimethylsiloxane, hexadecylsilane, or methacrylsilane.

6. The composition of claim 1 , wherein said second part comprises as ingredients about 0.001 to about 1% by weight one or more catalyst(s).

7. The composition of claim 1 , wherein said second part comprises as ingredients about 0.005 to about 0.05% by weight one or more catalyst(s).

8. The composition of claim 1 , wherein polymer C has an average molecular weight above about 500 Da, about 800 Da, about 1,500 Da, about 3,000 Da, or about 6,000 Da.

9. The composition of claim 1 , wherein polymer C has an average molecular weight of about 10,000 Da.

10. The composition of claim 1 , wherein polymer C comprises vinyl dimethicone.

11. The composition of claim 1 , wherein said reinforcing component have an average surface area of between about 50 and about 500 m 2 /g, between about 100 and about 350 m 2 /g, or between about 135 and about 250 m 2 /g.

12. The composition of claim 1 , wherein the ratio of weight or volume amount of the first part to the second part is about 2:1 to about 1:2.

13. The composition of claim 1 , wherein the first part is anhydrous, and wherein the second part is anhydrous.

14. The composition of claim 1 , wherein the layer formed over the skin of the subject has a glass transition temperature below about 37° C.

15. The composition of claim 1 , wherein polymer A has an average molecular weight of about 155,000 Da.

16. The composition of claim 1 , wherein the catalyst is platinum catalyst.

17. The composition of claim 1 , wherein the catalyst is platinum divinyltetramethyldisiloxane complex.

Assignments (3)

Continuity (3)

References Cited (226)