Omega-3 compositions, dosage forms, and methods of use
Omega-3 compositions, dosage forms, and methods of use are disclosed herein. The omega-3 compositions and dosage forms disclosed herein may comprise DHA and EPA at a ratio of about 5:2. The omega-3 compositions and dosage forms disclosed herein may comprise re-esterified triglycerides. Methods of treatment using the compositions and dosage forms are also disclosed.
1. A composition comprising:
a processed marine oil composition comprising fatty acid esters, wherein the fatty acid esters comprise esters of omega-3 polyunsaturated fatty acids (PUFAs), including esters of 4Z,7Z,10Z,13Z, 16Z,19Z-docosahexaenoic acid (DHA) and esters of 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid (EPA);
wherein a ratio of esters of DHA to esters of EPA is about 2.5:1 to about 4:1;
wherein about 55 wt % to about 70 wt % of the fatty acid esters are in the form of triglycerides (TGs);
wherein about 25 wt % to about 45 wt % of the fatty acids esters are in the form of diglycerides (DGs); and
wherein the TGs and DGs are re-esterified triglycerides (rTGs) and re-esterified diglycerides (rDGs).
2. The composition of claim 1 , wherein the ratio of esters of DHA to esters of EPA is about 5:2.
3. The composition of claim 1 , wherein about 0 wt % to about 5 wt % of the fatty acid esters are in the form of monoglycerides (MGs).
4. The composition of claim 1 , wherein about 5 wt % or less of the fatty acid esters are in the form of ethyl esters.
5. The composition of claim 1 , wherein at least about 60 wt % of the fatty acid esters are esters of PUFAs.
6. The composition of claim 1 , wherein at least about 50 wt % of the fatty acid esters are either esters of DHA or esters of EPA.
7. The composition of claim 1 , wherein about 0 wt % to about 35 wt % of the fatty acid esters are esters of mono-unsaturated fatty acids.
8. The composition of claim 1 , wherein about 0 wt % to about 5 wt % of the fatty acid esters are esters of saturated fatty acids.
9. The composition of claim 1 , wherein at least about 15 wt % of the marine oil is derived from cephalopod oil.
10. A dosage form comprising:
a processed marine oil composition comprising fatty acid esters, wherein the fatty acid esters comprise esters of omega-3 polyunsaturated fatty acids (PUFAs), including at least about 450 mg of esters of 4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoic acid (DHA) and at least about 150 mg of esters of 5Z,8Z,11Z,14Z,17Z-eicosapentaenoic acid (EPA);
wherein about 55 wt % to about 70 wt % of the fatty acid esters are in the form of triglycerides (TGs);
wherein about 25 wt % to about 45 wt % of the fatty acid esters are in the form of diglycerides (DGs);
wherein the TGs and DGs are re-esterified triglycerides (rTGs) and re-esterified diglycerides (rDGs).
11. The dosage form of claim 10 , wherein a ratio of esters of DHA to esters of EPA is about 3:2 to about 4:1.
12. The dosage form of claim 10 , wherein the amount of esters of DHA is about 450 mg to about 700 mg.
13. The dosage form of claim 10 , wherein the amount of esters of EPA is about 150 mg to about 300 mg.
14. The dosage form of claim 10 , wherein a mass of the dosage form is about 1200 mg to about 1600 mg.