Use of pegylated IL-10 to treat cancer
Provided are methods of treatment for tumors. In particular, methods are provided for use of a chemically modified IL-10 to treat tumors.
1. A method of inhibiting or reducing growth of a tumor or cancer in a subject in need thereof, the method comprising:
administering to the subject an effective amount of a pegylated interleukin-10 (PEG-IL-10) in combination with a folic acid analog, 5-fluorouracil and a platinum analog.
2. The method of claim 1 , wherein the PEG-IL-10 comprises a methoxy-PEG-aldehyde (PALD-PEG) linker.
3. The method of claim 1 , wherein the tumor or cancer is selected from the group consisting of colon cancer, ovarian cancer, breast cancer, melanoma, lung cancer, glioblastoma, and lymphoma.
4. The method of claim 3 , wherein the subject is human.
5. The method of claim 4 , wherein the PEG-IL-10 is human PEG-IL-10 (PEG-hIL-10).
6. The method of claim 1 , wherein the tumor or cancer is selected from the group consisting of epithelial cell cancer, endothelial cell cancer, squamous cell carcinoma, papillomavirus-induced cancer, adenocarcinoma, carcinoma, melanoma, sarcoma, and teratocarcinoma.
7. The method of claim 6 , wherein the subject is human.
8. The method of claim 7 , wherein the PEG-IL-10 is human PEG-IL-10 (PEG-hIL-10).