Synthetic plasmodium antigens, compositions, and uses thereof
Provided herein are synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof. Also provided herein are methods of treating and/or preventing Plasmodium infection and/or disease by administering the synthetic P. vivax antigens, antibodies and pharmaceutical formulations and vaccines thereof.
1. A protein comprising:
a synthetic Plasmodium vivax polypeptide comprising the amino acid sequence SEQ ID NO: 3.
2. A formulation comprising:
an amount of the protein of claim 1 ; and
a pharmaceutically acceptable carrier.
3. The formulation of claim 2 , further comprising an adjuvant.
4. The formulation of claim 2 , wherein the amount of the protein is an amount effective to induce an immune response in a subject.
5. The formulation of claim 2 , wherein the amount of the protein is an amount effective to induce antibody production in a subject.
6. The formulation of claim 2 , wherein the amount of the protein is an amount effective to reduce or inhibit Duffy Binding Protein (DBP) binding to a Duffy Antigen Receptor for Chemokines.
7. The formulation of claim 2 , wherein the synthetic P. vivax polypeptide consists of the amino acid sequence SEQ ID NO: 3.
8. The protein of claim 1 , wherein the synthetic P. vivax polypeptide consists of the amino acid sequence SEQ ID NO: 3.