Ketone supplements for treatment of angelman syndrome
The invention concerns a method of treating Angelman Syndrome (AS) in a subject, comprising inducing ketosis in the subject by administering a therapeutically effective amount of a ketone ester, such as an R,S-1,3-butanediol acetoacetate ester, wherein administration of the ketone ester elevates the blood ketone level in the subject. Other aspects of the invention include a method of increasing cognitive function and/or motor function in a subject with AS; and a method of decreasing seizures and increasing the latency to seize in a subject with AS.
1. A method of treating Angelman Syndrome (AS) in a subject, comprising inducing ketosis in the subject by administering a ketone supplement to the subject.
2. The method of claim 1 , wherein the ketone supplement comprises β-hydroxybutyrate (BHB) salt.
3. The method of claim 2 , wherein the ketone supplement comprises a mixture of the BHB salt and a medium chain triglyceride (MCT).
4. The method of claim 2 , wherein the BHB salt is a sodium/calcium BHB salt.
5. The method of claim 1 , wherein the ketone supplement comprises a ketone ester.
6. A method of increasing cognitive function and/or motor function in a subject with Angelman Syndrome (AS), comprising inducing ketosis in the subject by administering a ketone supplement to the subject.
7. The method of claim 6 , wherein the ketone supplement comprises β-hydroxybutyrate (BHB) salt.
8. The method of claim 7 , wherein the ketone supplement comprises a mixture of the BHB salt and a medium chain triglyceride (MCT).
9. The method of claim 7 , wherein the BHB salt is a sodium/calcium BHB salt.
10. The method of claim 6 , wherein the ketone supplement comprises a ketone ester.
11. A method of decreasing seizures, increasing the latency to seize, and/or increasing the ratio of hippocampal gamma-amino butyric acid (GABA) to glutamate in a subject with Angelman Syndrome (AS), comprising inducing ketosis in the subject by administering a ketone supplement to the subject.
12. The method of claim 11 , wherein the ketone supplement comprises β-hydroxybutyrate (BHB) salt.
13. The method of claim 12 , wherein the ketone supplement comprises a mixture of the BHB salt and a medium chain triglyceride (MCT).
14. The method of claim 13 , wherein the BHB salt is a sodium/calcium BHB salt.
15. The method of claim 11 , wherein the ketone supplement comprises a ketone ester.