(20S)-1-α,25-dihydroxy-24,24-difluoro-19-nor-vitamin D
Disclosed are 1α,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
1. A compound having the formula:
where X 1 , X 2 , and X 3 , which may be the same or different, are each independently selected from hydrogen or a hydroxy-protecting group.
2. The compound of claim 1 wherein X 1 is hydrogen.
3. The compound of claim 1 wherein X 2 is hydrogen.
4. The compound of claim 1 wherein X 1 and X 2 are both t-butyldimethylsilyl.
5. The compound of claim 1 wherein X 3 is hydrogen.
6. The compound of claim 1 wherein X 3 is triethylsilyl.
7. The compound of claim 1 having a formula:
8. A pharmaceutical composition containing an effective amount of the compound of claim 1 or a pharmaceutical salt thereof together with a pharmaceutically acceptable excipient.
9. The pharmaceutical composition of claim 8 wherein said effective amount comprises about 1.0 μg to about 1000.0 μg per gram of the composition.