Nucleic acids and proteins from streptococcus groups A and B
The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
1. A fusion polypeptide comprising (i) a polypeptide which has at least 95% sequence identity to SEQ ID NO: 4212 and (ii) a heterologous sequence.
2. The fusion polypeptide of claim 1 , wherein the polypeptide of (i) comprises a sequence which has at least 99% sequence identity to SEQ ID NO: 4212.
3. The fusion polypeptide of claim 2 , wherein the polypeptide of (i) comprises the sequence of SEQ ID NO: 4212.
4. The fusion polypeptide of claim 1 , wherein the heterologous sequence of the fusion polypeptide comprises a histidine tag, a glutathione S-transferase (GST) tag, a signal sequence, or a leader sequence.
5. A composition comprising (a) a fusion polypeptide of claim 1 , and (b) a pharmaceutically acceptable vehicle.