Disubstituted maleic anhydrides with altered kinetics of ring closure
We describe anhydride compounds suitable for physiologically labile modification of amine-containing molecules. The described anhydrides form reversible linkages having desirable kinetics for in vivo delivery of biologically active molecules. Also described are endosomolytic polymers formed by modification of membrane active polyamines with the described anhydrides.
1. An anhydride comprising the structure represented by:
wherein n is an integer from 1 to 8; and
Z comprises a carboxyl group, a hydroxyl group, an ester group, an amide group, an ether group, a tertiary amine group, a protected amine group, a targeting group, or a steric stabilizer group.
2. The anhydride of claim 1 , wherein:
Z is selected from the group consisting of: hydroxyl group, targeting group, and steric stabilizer group.
3. The anhydride of claim 1 , wherein the targeting group is an N-acetylgalactosamine.
4. The anhydride of claim 1 , wherein the steric stabilizer is a polyethyleneglycol.
5. The anhydride of claim 1 , wherein Z comprises polyethylene glycol.
6. The anhydride of claim 1 , wherein n is 1.
7. The anhydride of claim 1 , wherein n is 2.