Granted Patent
B2
US 12,611,465 · App. 19/079,771 · Granted Apr 28, 2026
Protein-enclosing polymeric micelle
Inventors:
Horacio Cabral (Tokyo, JP); Anqi Tao (Tokyo, JP); Kazunori Igarashi (Tokyo, JP); Takuya Miyazaki (Tokyo, JP); George Lo Huang (Tokyo, JP); Pengwen Chen (Tokyo, JP)
Assignee:
THE UNIVERSITY OF TOKYO
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Abstract
The present invention provides a polymeric complex comprising a protein and a block copolymer represented by the following formula (1):
Claims (23)
1 . A block copolymer represented by the following formula (1):
wherein R 1 and R 2 each independently represent a hydrogen atom, or a linear or branched alkyl group containing 1 to 12 carbon atoms,
R 3 represents a group represented by the following formula (Ia) or (Ib):
L 1 represents a group represented by the following formula (11):
—(CH 2 ) p1 —NH— (11),
wherein p1 represents an integer of 1 to 6,
m1 represents an integer of 0 to 500 and m2 represents an integer greater than 0 up to 500, provided that the sum of m1 and m2 represents an integer of 10 to 500,
m3, m4 and m5 each independently represent an integer of 1 to 5,
n represents an integer of 0 to 500, and
the symbol “/” means that (m1+m2) units of the respective monomer units shown on the left and right sides of this symbol may be in any sequence.
2 . The block copolymer according to claim 1 , wherein R 1 represents linear or branched alkyl group containing 1 to 12 carbon atoms.
3 . The block copolymer according to claim 1 , wherein R 1 represents alkyl group containing 1 carbon atom.
4 . The block copolymer according to claim 1 , wherein R 2 represents a hydrogen atom.
5 . The block copolymer according to claim 1 , wherein R 3 represents a group represented by the following formula (Ia):
6 . The block copolymer according to claim 1 , wherein R 3 represents a group represented by the following formula (Ib):
7 . The block copolymer according to claim 1 , wherein L 1 represents the following formula (11):
—(CH 2 ) p1 —NH— (11),
wherein p1 represents an integer of 1 to 6.
8 . The block copolymer according to claim 7 , wherein p1 represents an integer of 1.
9 . The block copolymer according to claim 1 , wherein m3 represents an integer of 4.
10 . The block copolymer according to claim 1 , wherein m4 represents an integer of 4.
11 . The block copolymer according to claim 1 , wherein m5 represents an integer of 2.
12 . The block copolymer according to claim 1 , wherein the block copolymer is represented by the following formula (2):
Continuity (3)
Continuation
17623144
Provisional Application
62868040
· Jun 28, 2019
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