Methods and devices for endovascular therapy
The present invention provides methods and devices for treating endovascular disease. Vibrational energy is delivered to change compliance and increase permeability at the treatment area. To improve clinical outcomes, one or more therapeutic drugs may be delivered to the treatment area.
1. A vibrational system for treating endovascular disease of a patient, comprising:
a signal generator that is capable of producing a signal at a frequency of 1 KHZ-10 MHZ and a power of less than 20 Watts, wherein the signal generator is configured to produce the signal in each of: (i) a continuous mode, whereupon operating in the continuous mode, the signal generator continuously produces ultrasound energy; (ii) a pulse mode, whereupon operating in the pulse mode, the signal generator produces ultrasound energy in pulses; and (iii) a modulated mode, whereupon operating in the modulated mode, the signal generator produces ultrasound energy in pulses and modulates the pulses to have varying pulse parameters;
a transducer coupled to the signal generator to convert the signal produced by the signal generator to vibrational energy;
an elongated ultrasound transmission member having a distal end configured to be inserted into the body of the patient, and a proximal end coupled to the transducer, wherein the elongated ultrasound transmission member is configured to propagate the vibrational energy received from the transducer at the proximal end of the transmission member through the transmission member to the distal end of the transmission member; and
a catheter having an irrigation lumen and an irrigation port in fluid communication with the irrigation lumen, wherein the catheter at least partially surrounds the ultrasound transmission member and is axially aligned proximally of the distal end of the elongated ultrasound transmission member to direct the surface waves from the distal portion of the transmission member toward a treatment area, wherein the irrigation port discharges an irrigation fluid through at least one outflow channel at the distal end of the catheter, and wherein the vibrational energy received from the transducer propagates toward the treatment area as the surface waves in the irrigation fluid discharged from the catheter;
wherein an anchor member is attached to the distal end and the ultrasound transmission member; and
wherein the distal end of the elongated transmission member extends outside of the catheter, and the system further includes a polymer sheath positioned along the distal end of the ultrasound transmission member and the anchor member, the polymer sheath having a smaller diameter than the catheter.
2. The system of claim 1 , wherein the signal generator is an extracorporeal device.
3. The system of claim 1 , wherein a polymer shell is positioned around the distal end of the ultrasound transmission member and is at least partially surrounding a radiopaque marker of the elongated ultrasound transmission member, the anchor member, and the ultrasound transmission member.
4. The system of claim 1 , wherein a separate tip is attached on the distal end of the ultrasound transmission member.
5. The system of claim 4 , wherein the anchor member is attached to the separate tip.
6. The system of claim 5 , further including a radiopaque marker positioned on the ultrasound transmission member.
7. The system of claim 6 , wherein a polymer shell is at least partially surrounding the ultrasound transmission member.
8. The system of claim 1 , wherein a radiopaque marker is attached to the distal end of the catheter.
9. The system of claim 1 , wherein the catheter includes a guidewire lumen.
10. The system of claim 1 , wherein the catheter is configurable to be repositioned along the ultrasound transmission member.
11. The system of claim 1 , wherein the ultrasound transmission member is connected at its proximal end to a sonic connector, wherein the ultrasound transmission member is surrounded by one or more absorbers positioned around the proximal end of the ultrasound transmission member.