Treatment of NAFLD and NASH
Treatment of NAFLD and NASH by therapy with MBX-8025 or an MBX-8025 salt.
1. A method of treating a disease that is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH) by orally administering a therapeutically effective amount of (R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)-acetic acid (MBX-8025) or a salt thereof.
2. The method of claim 1 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 20-200 mg/day.
3. The method of claim 2 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 50-100 mg/day.
4. The method of claim 1 where the MBX-8025 or a salt thereof is administered once/day.
5. A method of treating NAFLD by orally administering a therapeutically effective amount of MBX-8025 or a salt thereof.
6. The method of claim 5 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 20-200 mg/day.
7. The method of claim 6 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 50-100 mg/day.
8. The method of claim 5 where the MBX-8025 or a salt thereof is administered once/day.
9. A method of treating NASH by orally administering a therapeutically effective amount of MBX-8025 or a salt thereof.
10. The method of claim 9 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 20-200 mg/day.
11. The method of claim 10 where the daily dose of MBX-8025 or a salt thereof (when calculated as the free acid) is 50-100 mg/day.
12. The method of claim 9 where the MBX-8025 or a salt thereof is administered once/day.