Chlorhexidine gluconate compositions, resin systems and articles
Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.
1. A composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle having a hydrophilic-lipophilic balance of no greater than 10 as determined using the HLB Method,
wherein the hydrophobic vehicle comprises two proximate hydrogen-bonding groups,
wherein at least one of the hydrogen-bonding groups is a hydrogen donor,
wherein the composition comprises no greater than 0.1 parts by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate, and
wherein the hydrophobic vehicle is a monoacylglycerol.
2. The composition of claim 1 , wherein an alkyl group of the monoacylglycerol is a C8 to C18 alkyl group.
3. The composition of claim 1 , wherein the monoacylglycerol is selected from the group consisting of glycerol monocaprylate, glycerol monolaurate, glycerol monoisostearate, glycerol monooleate, and combinations thereof.
4. The composition according to claim 1 , wherein the composition comprises no greater than 0.1 parts by weight water per 1 part by weight chlorhexidine gluconate.
5. The composition according to claim 1 , further comprising a resin system comprising a polymer.
6. The composition of claim 5 , wherein the resin system comprises a hydrophobic phase, wherein the hydrophobic vehicle plasticizes the hydrophobic phase.
7. The composition of claim 5 , wherein the polymer comprises an acrylate polymer.
8. The composition of claim 5 , wherein the polymer comprises a block copolymer polymer.
9. The composition according to claim 6 , wherein the resin system is a pressure sensitive adhesive.
10. An article comprising a substrate and the composition according to claim 1 bonded to at least a portion of a surface of the substrate.
11. The article according to claim 10 , wherein the article is a medical article.
12. The composition of claim 1 , wherein the monoacylglycerol is a 1-monoacylglyceride.
13. A composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle having a hydrophilic-lipophilic balance of no greater than 10 as determined using the HLB Method,
wherein the hydrophobic vehicle comprises two proximate hydrogen-bonding groups,
wherein at least one of the hydrogen-bonding groups is a hydrogen donor,
wherein the composition comprises no greater than 0.1 parts by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate, and
wherein the hydrophobic vehicle is a vicinal diol.
14. The composition according to claim 13 , wherein the vicinal diol is a 1,2-diol.
15. The composition according to claim 14 , wherein the vicinal diol is selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octane diol, 1,2-decane diol, 1,2,6-trihydroxy-hexane, and combinations thereof.
16. The composition according to claim 14 , wherein the vicinal diol is selected from the group consisting of diethyl-D-tartrate, diethyl-L-tartrate, dibutyl-L-tartrate, decaglyceryl tristearate, 1,3-dihydroxyacetone dimer, 2,3-butanediol, ethylhexyl glycerin, and combinations thereof.
17. An article comprising a substrate and the composition according to claim 13 bonded to at least a portion of a surface of the substrate.
18. The article according to claim 17 , wherein the article is a medical article.
19. A composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle having a hydrophilic-lipophilic balance of no greater than 10 as determined using the HLB Method,
wherein the hydrophobic vehicle comprises two proximate hydrogen-bonding groups,
wherein at least one of the hydrogen-bonding groups is a hydrogen donor,
wherein the composition comprises no greater than 0.1 parts by weight hydrophilic vehicle per 1 part by weight chlorhexidine gluconate, and
wherein the hydrophobic vehicle is selected from the group consisting of 1,3-diols, 1,4-diols, and combinations thereof.
20. The composition according to claim 19 , wherein the 1,3-diol is selected from the group consisting of: 1,3-cyclohexanediol, 3-methyl-1,3-butanediol, 1,3-butanediol, 1,3-propanediol, and combinations thereof.