Pharmaceutical compositions comprising perillyl alcohol derivatives
A pharmaceutical composition is provided which includes perillyl alcohol conjugated with a therapeutic agent and further includes and a hydrolyzable acylated aliphatic tail. A method of using the pharmaceutical composition is also provided for treating a condition or disease of a patient, e.g., cancer.
1. A compound having a structural formula of
wherein R is selected from the group consisting of a C 4 to C 28 linear or branched alkyl, a linear or branched C 4 to C 28 alkeneyl and a linear or branched C 4 to C 28 alkynyl group; or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein R is a C 4 to C 28 linear or branched alkeneyl containing 1, 2, 3, 4 or 5 double bonds; or a linear or brandied C 4 to C 28 alkynyl group containing 1, 2, 3, 4 or 5 triple bonds.
3. The compound according to claim 1 having a structural formula of:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising the compound of claim 1 , 2 or 3 .