Cancer treatment using viruses and camptothecins
Mammalian subjects having a neoplasm are treated with a virus and a camptothecin compound, for example irinotecan or topotecan. The virus is selected from the group consisting of a Newcastle disease virus, a measles virus, a vesicular stomatitis virus, an influenza virus, a Sindbis virus, a picornavirus, and a myxoma virus. The treatment can also include administration of a monoclonal antibody against epidermal growth factor receptor, for example cetuximab.
1. A method of treating a mammalian subject having a neoplasm, comprising administering to the subject a Newcastle disease yirus and a camptothecin compound in a combined amount effective to treat the subject.
2. The method of claim 1 , further comprising administering to the subject a monoclonal antibody against epidermal growth factor receptor in an amount effective, in combination with the virus and the camptothecin compound, to treat the subject.
3. The method of claim 2 , wherein the monoclonal antibody is cetuximab.
4. The method of claim 1 , wherein the virus is replication-competent.
5. The method of claim 1 , wherein the virus is a mesogenic strain of Newcastle disease virus.
6. The method of claim 1 , wherein the virus is administered intravenously.
7. The method of claim 1 wherein the camptothecin compound is selected from the group consisting of topotecan, 9-aminocamptothecin, exatecan, karenitecin, rubitecan, lurtotecan, and a homocamptothecin.
8. The method of claim 1 , wherein the camptothecin compound is irinotecan.
9. The method of claim 1 , wherein the camptothecin compound and the virus are administered to the subject within a single twenty-four hour period.
10. The method of claim 1 , wherein the camptothecin compound is administered from twenty-four hours to one month before administration of the virus.
11. The method of claim 10 , wherein the camptothecin compound is administered from twenty-four hours to one week before administration of the virus.
12. The method of claim 1 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one month after administration of the virus.
13. The method of claim 12 , wherein the camptothecin compound is administered to the subject from twenty-four hours to one week after administration of the virus.