Cyclic-GluR6 analogs, methods of treatment and use
A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R 1 is at least about one amino acid covalently bound; and, R 2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
1. A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising
wherein
R is a molecular transporter with or without a linker amino acid;
R 1 is at least about one amino acid covalently bound; and,
R 2 is isoleucine, leucine, alanine, phenylalanine, or valine
and wherein the P −4 position is indicated.
2. The composition of claim 1 wherein R 1 is β-alanine.
3. The composition of claim 1 wherein R 2 is valine.
4. The composition of claim 1 wherein the P −4 position is lysine, aspartic acid, glutamic acid or arginine.
5. The composition of claim 1 having the structure:
6. The composition of claim 1 wherein R comprises a liposome, steroid, polyamine, nanotube, nanoparticle, dendrimer, cell-penetrating peptide, protein-transduction domain amino acid, peptoid, N-substituted glycine, oligogcarbamate, arginine oligomer of about 6-20 units (SEQ ID NO: 2), D-arginine oligomer, spaced arginine oligomer, N-arginine peptoid, oligoarbamate transporter, or tetrameric dendrimer.
7. The inhibitor of claim 1 wherein R comprises (SEQ ID NO: 3):